Gain-of-function mutation W493R in the epithelial sodium channel allosterically reconfigures intersubunit coupling

Keyphrases

• Gain-of-function mutation 100%
• Reconfiguration 100%
• Epithelial Sodium Channel (ENaC) 100%
• Kidney 10%
• Site-directed mutagenesis 10%
• Molecular Dynamics Simulation 10%
• Molecular Dynamics 10%
• Lung 10%
• Electrostatic Interaction 10%
• Epithelial Cells 10%
• Voltage Clamp 10%
• Pathophysiological Conditions 10%
• Cystic Fibrosis 10%
• Structure Dynamics 10%
• Cause of Disease 10%
• Mutagenesis Studies 10%
• Quaternary Structure 10%
• Rate Limiting 10%
• Structural Dynamics 10%
• Channel Gating 10%
• Channel Activation 10%
• Gain-of-function 10%
• Distal Colon 10%
• Sodium Absorption 10%
• Homology Modeling 10%
• Acidic Patch 10%
• Disease-causing mutations 10%
• Driving Model 10%
• Sodium Binding 10%
• Liddle Syndrome 10%

Immunology and Microbiology

• Dynamics 100%
• Sodium Channel 100%
• Gain of Function Mutation 100%
• Cross Linking 40%
• Site Directed Mutagenesis 20%
• Colon 20%
• Protein Quaternary Structure 20%
• Molecular Model 20%
• Static Electricity 20%
• Voltage Clamp Technique 20%
• Cysteine 20%

Biochemistry, Genetics and Molecular Biology

• Gain of Function Mutation 100%
• Epithelial Sodium Channel 100%
• Dynamics 45%
• Cross-Link 18%
• Site-Directed Mutagenesis 9%
• Cystic Fibrosis 9%
• Colon 9%
• Protein Quaternary Structure 9%
• Static Electricity 9%
• Homology Modeling 9%
• Voltage Clamp 9%
• Sodium Absorption 9%
• Disorders of Calcium Metabolism 9%