TY - JOUR
T1 - Gangliosides
T2 - Glycosphingolipids essential for normal neural development and function
AU - Schengrund, Cara Lynne
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs). Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain, can affect neuronal function by modulating cell signaling. This review summarizes changes in ganglioside expression during brain development, the specific effects they induce, and makes observations about their possible role(s) in dementing diseases. Given that the average lifespan of individuals in many countries has increased, and that aging is accompanied by an increasing probability of dementia, understanding how changes in the GSL composition of lipid rafts may contribute to the cell biological basis of a specific dementing phenotype is an important area of study.
AB - Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs). Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain, can affect neuronal function by modulating cell signaling. This review summarizes changes in ganglioside expression during brain development, the specific effects they induce, and makes observations about their possible role(s) in dementing diseases. Given that the average lifespan of individuals in many countries has increased, and that aging is accompanied by an increasing probability of dementia, understanding how changes in the GSL composition of lipid rafts may contribute to the cell biological basis of a specific dementing phenotype is an important area of study.
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U2 - 10.1016/j.tibs.2015.03.007
DO - 10.1016/j.tibs.2015.03.007
M3 - Review article
C2 - 25941169
AN - SCOPUS:84930819900
SN - 0968-0004
VL - 40
SP - 397
EP - 406
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 7
ER -