GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion

Jianwei Sun; Huifang He; Smitha Pillai; Yin Xiong; Sridevi Challa; Liyan Xu; Srikumar Chellappan; Shengyu Yang

doi:10.1074/jbc.M113.506535

GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion

Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan, Shengyu Yang

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Background: Fascin is a pro-metastasis actin bundling protein overexpressed in basal-like breast cancer. Results: GATA3 abrogates TGFβ and Smad4-mediated fascin overexpression by abolishing the binding of Smad4 to fascin promoter. Conclusion: GATA3 is a novel suppressor of the canonical TGFβ-Smad signaling pathway. Significance: These findings provide mechanistic insight into how TGFβ-mediated invasion and metastasis are differentially regulated in different subgroups of breast cancer.

Original language	English (US)
Pages (from-to)	36971-36982
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.506535
State	Published - Dec 27 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.506535

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title = "GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion",

abstract = "Background: Fascin is a pro-metastasis actin bundling protein overexpressed in basal-like breast cancer. Results: GATA3 abrogates TGFβ and Smad4-mediated fascin overexpression by abolishing the binding of Smad4 to fascin promoter. Conclusion: GATA3 is a novel suppressor of the canonical TGFβ-Smad signaling pathway. Significance: These findings provide mechanistic insight into how TGFβ-mediated invasion and metastasis are differentially regulated in different subgroups of breast cancer.",

author = "Jianwei Sun and Huifang He and Smitha Pillai and Yin Xiong and Sridevi Challa and Liyan Xu and Srikumar Chellappan and Shengyu Yang",

year = "2013",

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doi = "10.1074/jbc.M113.506535",

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T1 - GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion

AU - Sun, Jianwei

AU - He, Huifang

AU - Pillai, Smitha

AU - Xiong, Yin

AU - Challa, Sridevi

AU - Xu, Liyan

AU - Chellappan, Srikumar

AU - Yang, Shengyu

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: Fascin is a pro-metastasis actin bundling protein overexpressed in basal-like breast cancer. Results: GATA3 abrogates TGFβ and Smad4-mediated fascin overexpression by abolishing the binding of Smad4 to fascin promoter. Conclusion: GATA3 is a novel suppressor of the canonical TGFβ-Smad signaling pathway. Significance: These findings provide mechanistic insight into how TGFβ-mediated invasion and metastasis are differentially regulated in different subgroups of breast cancer.

AB - Background: Fascin is a pro-metastasis actin bundling protein overexpressed in basal-like breast cancer. Results: GATA3 abrogates TGFβ and Smad4-mediated fascin overexpression by abolishing the binding of Smad4 to fascin promoter. Conclusion: GATA3 is a novel suppressor of the canonical TGFβ-Smad signaling pathway. Significance: These findings provide mechanistic insight into how TGFβ-mediated invasion and metastasis are differentially regulated in different subgroups of breast cancer.

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SP - 36971

EP - 36982

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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ER -

GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion

Abstract

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