GDF-15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme

Zahra Hasanpour Segherlou, Masoud Nouri-Vaskeh, Sama Noroozi Guilandehi, Amir Baghbanzadeh, Ramin Zand, Behzad Baradaran, Mohammad Zarei

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis. According to the aggressive form of GBM, understanding the accurate molecular mechanism associated with GBM pathogenesis is essential. Growth differentiation factor 15 (GDF-15) belongs to transforming growth factor-β superfamily with important roles to control biological processes. It affects cancer growth and progression, drug resistance, and metastasis. It also can promote stemness in many cancers, and also can stress reactions control, bone generation, hematopoietic growth, adipose tissue performance, and body growth, and contributes to cardiovascular disorders. The role GDF-15 to develop and progress cancer is complicated and remains unclear. GDF-15 possesses tumor suppressor properties, as well as an oncogenic effect. GDF-15 antitumorigenic and protumorigenic impacts on tumor development are linked to the cancer type and stage. However, the GDF-15 signaling and mechanism have not yet been completely identified because of no recognized cognate receptor.

Original languageEnglish (US)
Pages (from-to)5564-5581
Number of pages18
JournalJournal of Cellular Physiology
Issue number8
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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