TY - JOUR
T1 - Gene Editing in Rabbits
T2 - Unique Opportunities for Translational Biomedical Research
AU - Xu, Jie
AU - Zhang, Jifeng
AU - Yang, Dongshan
AU - Song, Jun
AU - Pallas, Brooke
AU - Zhang, Chen
AU - Hu, Jiafen
AU - Peng, Xuwen
AU - Christensen, Neil D.
AU - Han, Renzhi
AU - Chen, Y. Eugene
N1 - Publisher Copyright:
© Copyright © 2021 Xu, Zhang, Yang, Song, Pallas, Zhang, Hu, Peng, Christensen, Han and Chen.
PY - 2021/1/28
Y1 - 2021/1/28
N2 - The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edited (GE) rabbit models, compared to their counterpart mouse models, may offer unique opportunities in translational biomedical research attributed primarily to their relatively large size and long lifespan. More importantly, GE rabbit models have been found to mimic several disease pathologies better than their mouse counterparts particularly in fields focused on genetically inherited diseases, cardiovascular diseases, ocular diseases, and others. In this review we present selected examples of research areas where GE rabbit models are expected to make immediate contributions to the understanding of the pathophysiology of human disease, and support the development of novel therapeutics.
AB - The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edited (GE) rabbit models, compared to their counterpart mouse models, may offer unique opportunities in translational biomedical research attributed primarily to their relatively large size and long lifespan. More importantly, GE rabbit models have been found to mimic several disease pathologies better than their mouse counterparts particularly in fields focused on genetically inherited diseases, cardiovascular diseases, ocular diseases, and others. In this review we present selected examples of research areas where GE rabbit models are expected to make immediate contributions to the understanding of the pathophysiology of human disease, and support the development of novel therapeutics.
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U2 - 10.3389/fgene.2021.642444
DO - 10.3389/fgene.2021.642444
M3 - Review article
C2 - 33584832
AN - SCOPUS:85101034961
SN - 1664-8021
VL - 12
JO - Frontiers in Genetics
JF - Frontiers in Genetics
M1 - 642444
ER -