TY - JOUR
T1 - Gene-environment contributions to the development of infant vagal reactivity
T2 - The interaction of dopamine and maternal sensitivity
AU - Propper, Cathi
AU - Moore, Ginger A.
AU - Mills-Koonce, W. Roger
AU - Halpern, Carolyn Tucker
AU - Hill-Soderlund, Ashley L.
AU - Calkins, Susan D.
AU - Carbone, Mary Anna
AU - Cox, Martha
PY - 2008/9
Y1 - 2008/9
N2 - This study investigated dopamine receptor genes (DRD2 and DRD4) and maternal sensitivity as predictors of infant respiratory sinus arrhythmia (RSA) and RSA reactivity, purported indices of vagal tone and vagal regulation, in a challenge task at 3, 6, and 12 months in 173 infant-mother dyads. Hierarchical linear modeling (HLM) revealed that at 3 and 6 months, RSA withdrawal in response to maternal separation was greater (suggesting expected physiological regulation) in infants without the DRD2 risk allele than those with the risk allele. At 12 months, infants with the risk allele who were also exposed to maternal sensitivity showed levels of RSA withdrawal comparable to infants who were not at genetic risk. Findings demonstrate the importance of developmental analysis of gene-environment interaction.
AB - This study investigated dopamine receptor genes (DRD2 and DRD4) and maternal sensitivity as predictors of infant respiratory sinus arrhythmia (RSA) and RSA reactivity, purported indices of vagal tone and vagal regulation, in a challenge task at 3, 6, and 12 months in 173 infant-mother dyads. Hierarchical linear modeling (HLM) revealed that at 3 and 6 months, RSA withdrawal in response to maternal separation was greater (suggesting expected physiological regulation) in infants without the DRD2 risk allele than those with the risk allele. At 12 months, infants with the risk allele who were also exposed to maternal sensitivity showed levels of RSA withdrawal comparable to infants who were not at genetic risk. Findings demonstrate the importance of developmental analysis of gene-environment interaction.
UR - http://www.scopus.com/inward/record.url?scp=51949086760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51949086760&partnerID=8YFLogxK
U2 - 10.1111/j.1467-8624.2008.01194.x
DO - 10.1111/j.1467-8624.2008.01194.x
M3 - Article
C2 - 18826531
AN - SCOPUS:51949086760
SN - 0009-3920
VL - 79
SP - 1377
EP - 1394
JO - Child development
JF - Child development
IS - 5
ER -