Gene-gene interactions: An essential component to modeling complexity for precision medicine

Molly A. Hall; Brian S. Cole; Jason H. Moore

doi:10.1016/B978-0-12-809633-8.20213-6

Gene-gene interactions: An essential component to modeling complexity for precision medicine

Molly A. Hall, Brian S. Cole, Jason H. Moore

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Association methods in the biomedical sciences often focus on one genetic locus at a time. Alternately, studying gene-gene interactions, or epistasis, allows discovery of genetic regions that modulate the effect of other loci. With precision medicine as the goal of biomedical research, genetic interactions are essential to uncovering the still unknown complex mechanisms which lead to common diseases. This article delves into the fundamental background of genetic interactions, a history of this field of study, major challenges to identifying gene-gene models, and common methods to overcome these challenges. Finally, further complexity beyond genetic interactions will be considered.

Original language	English (US)
Title of host publication	Encyclopedia of Bioinformatics and Computational Biology
Subtitle of host publication	ABC of Bioinformatics
Publisher	Elsevier
Pages	171-177
Number of pages	7
Volume	1-3
ISBN (Electronic)	9780128114322
ISBN (Print)	9780128114148
DOIs	https://doi.org/10.1016/B978-0-12-809633-8.20213-6
State	Published - Jan 1 2018

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/B978-0-12-809633-8.20213-6

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ER -

Gene-gene interactions: An essential component to modeling complexity for precision medicine

Abstract

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