TY - JOUR
T1 - Gene regulation by nucleosome positioning
AU - Bai, Lu
AU - Morozov, Alexandre V.
N1 - Funding Information:
The authors acknowledge Dr Fred Cross and Dr Eric Siggia for advice on the manuscript, and thank Dr Denis Tolkunov for help with the figures. L.B is supported by a Damon Runyon Cancer Research Fellowship, and A.V.M by an NIH grant HG004708 and an Alfred P. Sloan Research Fellowship.
PY - 2010/11
Y1 - 2010/11
N2 - To achieve high compaction, most genomic DNA in eukaryotes is incorporated into nucleosomes; however, regulatory factors and transcriptional machinery must gain access to chromatin to extract genetic information. This conflict is partially resolved by a particular arrangement of nucleosome locations on the genome. Across all eukaryotic species, promoters and other regulatory sequences are more nucleosome-depleted, whereas transcribed regions tend to be occupied with well-positioned, high-density nucleosomal arrays. This nucleosome positioning pattern, as well as its dynamic regulation, facilitates the access of transcription factors to their target sites and plays a crucial role in determining the transcription level, cell-to-cell variation and activation or repression dynamics.
AB - To achieve high compaction, most genomic DNA in eukaryotes is incorporated into nucleosomes; however, regulatory factors and transcriptional machinery must gain access to chromatin to extract genetic information. This conflict is partially resolved by a particular arrangement of nucleosome locations on the genome. Across all eukaryotic species, promoters and other regulatory sequences are more nucleosome-depleted, whereas transcribed regions tend to be occupied with well-positioned, high-density nucleosomal arrays. This nucleosome positioning pattern, as well as its dynamic regulation, facilitates the access of transcription factors to their target sites and plays a crucial role in determining the transcription level, cell-to-cell variation and activation or repression dynamics.
UR - http://www.scopus.com/inward/record.url?scp=77957883572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957883572&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2010.08.003
DO - 10.1016/j.tig.2010.08.003
M3 - Review article
C2 - 20832136
AN - SCOPUS:77957883572
SN - 0168-9525
VL - 26
SP - 476
EP - 483
JO - Trends in Genetics
JF - Trends in Genetics
IS - 11
ER -