Gene therapy utilizing drug resistance genes: A review

Debabrata Banerjee; Shi Cheng Zhao; Ming‐Xia ‐X Li; Barry I. Schweitzer; Shin Mineishi; Joseph R. Bertino

doi:10.1002/stem.5530120404

Gene therapy utilizing drug resistance genes: A review

Debabrata Banerjee, Shi Cheng Zhao, Ming‐Xia ‐X Li, Barry I. Schweitzer, Shin Mineishi, Joseph R. Bertino

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Abstract

The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

Original language	English (US)
Pages (from-to)	378-385
Number of pages	8
Journal	STEM CELLS
Volume	12
Issue number	4
DOIs	https://doi.org/10.1002/stem.5530120404
State	Published - 1994

All Science Journal Classification (ASJC) codes

Molecular Medicine
Developmental Biology
Cell Biology

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10.1002/stem.5530120404

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title = "Gene therapy utilizing drug resistance genes: A review",

abstract = "The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.",

author = "Debabrata Banerjee and Zhao, {Shi Cheng} and Li, {Ming‐Xia ‐X} and Schweitzer, {Barry I.} and Shin Mineishi and Bertino, {Joseph R.}",

year = "1994",

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AU - Schweitzer, Barry I.

AU - Mineishi, Shin

AU - Bertino, Joseph R.

PY - 1994

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AB - The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

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Gene therapy utilizing drug resistance genes: A review

Abstract

All Science Journal Classification (ASJC) codes

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