TY - JOUR
T1 - Genes and environment in neonatal intraventricular hemorrhage
AU - Gene targets for IVH study group
AU - Neonatal research network genomics study group
AU - Ment, Laura R.
AU - Ådén, Ulrika
AU - Bauer, Charles R.
AU - Bada, Henrietta S.
AU - Carlo, Waldemar A.
AU - Kaiser, Jeffrey R.
AU - Lin, Aiping
AU - Cotten, Charles Michael
AU - Murray, Jeffrey
AU - Page, Grier
AU - Hallman, Mikko
AU - Lifton, Richard P.
AU - Zhang, Heping
AU - Bryant, Cindy
AU - Cassady, Christopher
AU - Garcia, Carmen
AU - Johnson, Yvette R.
AU - Karpen, Heidi E.
AU - Munden, Martha M.
AU - Shores, Geneva
AU - Cassese, John
AU - Hensman, Angelita M.
AU - Vieira, Elisa
AU - Vohr, Betty
AU - Wallach, Michael
AU - Cummings, James J.
AU - MacGilvray, Scott S.
AU - Moseley, Sherry
AU - Trapanotto, Vickie
AU - Poindexter, Brenda
AU - Wilson, Leslie Dawn
AU - Wright-Coltart, Shirley
AU - Bartocci, Marco
AU - Printz, Gordana
AU - Hopper, Andrew
AU - Smith, Leon
AU - Wood, Beverly P.
AU - Young, Lionel
AU - Allan, Walter C.
AU - Alfsson, Jessica
AU - Sävman, Karin
AU - Royal, Stuart A.
AU - Young, Daniel W.
AU - Cosby, Shirley
AU - Helms, Crystal
AU - Angtuaco, Teresita
AU - Carol Sikes, N.
AU - Mason, Melanie J.
AU - Whit Hall, R.
AU - Challa, Harigovinda R.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/12
Y1 - 2015/12
N2 - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
AB - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
UR - http://www.scopus.com/inward/record.url?scp=84946738462&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946738462&partnerID=8YFLogxK
U2 - 10.1053/j.semperi.2015.09.006
DO - 10.1053/j.semperi.2015.09.006
M3 - Review article
C2 - 26516117
AN - SCOPUS:84946738462
SN - 0146-0005
VL - 39
SP - 592
EP - 603
JO - Seminars in Perinatology
JF - Seminars in Perinatology
IS - 8
ER -