Genetic adaptation to historical pathogen burdens

Johannes W. Fedderke; Robert E. Klitgaard; Valerio Napolioni

doi:10.1016/j.meegid.2017.07.017

Genetic adaptation to historical pathogen burdens

Johannes W. Fedderke, Robert E. Klitgaard, Valerio Napolioni

School of International Affairs

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.

Original language	English (US)
Pages (from-to)	299-307
Number of pages	9
Journal	Infection, Genetics and Evolution
Volume	54
DOIs	https://doi.org/10.1016/j.meegid.2017.07.017
State	Published - Oct 2017

All Science Journal Classification (ASJC) codes

Microbiology
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.meegid.2017.07.017

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title = "Genetic adaptation to historical pathogen burdens",

abstract = "Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.",

author = "Fedderke, {Johannes W.} and Klitgaard, {Robert E.} and Valerio Napolioni",

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T1 - Genetic adaptation to historical pathogen burdens

AU - Fedderke, Johannes W.

AU - Klitgaard, Robert E.

AU - Napolioni, Valerio

PY - 2017/10

Y1 - 2017/10

N2 - Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.

AB - Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.

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VL - 54

SP - 299

EP - 307

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

ER -

Genetic adaptation to historical pathogen burdens

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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