Genetic adaptation to historical pathogen burdens

Johannes W. Fedderke; Robert E. Klitgaard; Valerio Napolioni

doi:10.1016/j.meegid.2017.07.017

Genetic adaptation to historical pathogen burdens

Johannes W. Fedderke
, Robert E. Klitgaard
, Valerio Napolioni

School of International Affairs

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.

Original language	English (US)
Pages (from-to)	299-307
Number of pages	9
Journal	Infection, Genetics and Evolution
Volume	54
DOIs	https://doi.org/10.1016/j.meegid.2017.07.017
State	Published - Oct 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Microbiology (medical)
Infectious Diseases

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10.1016/j.meegid.2017.07.017

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title = "Genetic adaptation to historical pathogen burdens",

abstract = "Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.",

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T1 - Genetic adaptation to historical pathogen burdens

AU - Fedderke, Johannes W.

AU - Klitgaard, Robert E.

AU - Napolioni, Valerio

PY - 2017/10

Y1 - 2017/10

N2 - Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.

AB - Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.

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UR - https://www.scopus.com/pages/publications/85025628854#tab=citedBy

U2 - 10.1016/j.meegid.2017.07.017

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M3 - Article

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AN - SCOPUS:85025628854

SN - 1567-1348

VL - 54

SP - 299

EP - 307

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

ER -

Genetic adaptation to historical pathogen burdens

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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