Genetic and immunological complexity of major histocompatibility regions

Fritz H. Bach; Michael B. Widmer; Miriam Segall; Marilyn L. Bach; Jan Klein

doi:10.1126/science.176.4038.1024

Genetic and immunological complexity of major histocompatibility regions

Fritz H. Bach, Michael B. Widmer, Miriam Segall, Marilyn L. Bach, Jan Klein

Biology

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.

Original language	English (US)
Pages (from-to)	1024-1027
Number of pages	4
Journal	Science
Volume	176
Issue number	4038
DOIs	https://doi.org/10.1126/science.176.4038.1024
State	Published - 1972

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10.1126/science.176.4038.1024

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title = "Genetic and immunological complexity of major histocompatibility regions",

abstract = "There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.",

author = "Bach, {Fritz H.} and Widmer, {Michael B.} and Miriam Segall and Bach, {Marilyn L.} and Jan Klein",

year = "1972",

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T1 - Genetic and immunological complexity of major histocompatibility regions

AU - Bach, Fritz H.

AU - Widmer, Michael B.

AU - Segall, Miriam

AU - Bach, Marilyn L.

AU - Klein, Jan

PY - 1972

Y1 - 1972

N2 - There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.

AB - There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.

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Genetic and immunological complexity of major histocompatibility regions

Abstract

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