Genetic control of the serum concentration of an H-2-antigen-like polypeptide chain

Sune Kvist; Jan Klein; Per A. Peterson

doi:10.1007/BF01572584

Genetic control of the serum concentration of an H-2-antigen-like polypeptide chain

Sune Kvist, Jan Klein, Per A. Peterson

Biology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Mouse serum contains a protein complex consisting of at least three polypeptide chains. One of the chains with an approximate molecular weight of 40 000 is similar to the heavy chain of normal H-2 antigens. The serum concentration of this 40 000 dalton chain is under genetic control. Formal genetic analyses in B10.M and B10.S mice, their F₁ progeny and in backcrosses show that there are two codominantly expressed alleles at a single locus regulating the serum concentration. Measurements of the 40 000 dalton chain in recombinant mice suggest that the controlling locus is situated to the right of the S region.

Original language	English (US)
Pages (from-to)	499-507
Number of pages	9
Journal	Immunogenetics
Volume	10
Issue number	5
DOIs	https://doi.org/10.1007/BF01572584
State	Published - Oct 1980

All Science Journal Classification (ASJC) codes

Immunology
Genetics

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10.1007/BF01572584

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abstract = "Mouse serum contains a protein complex consisting of at least three polypeptide chains. One of the chains with an approximate molecular weight of 40 000 is similar to the heavy chain of normal H-2 antigens. The serum concentration of this 40 000 dalton chain is under genetic control. Formal genetic analyses in B10.M and B10.S mice, their F1 progeny and in backcrosses show that there are two codominantly expressed alleles at a single locus regulating the serum concentration. Measurements of the 40 000 dalton chain in recombinant mice suggest that the controlling locus is situated to the right of the S region.",

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AU - Klein, Jan

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N2 - Mouse serum contains a protein complex consisting of at least three polypeptide chains. One of the chains with an approximate molecular weight of 40 000 is similar to the heavy chain of normal H-2 antigens. The serum concentration of this 40 000 dalton chain is under genetic control. Formal genetic analyses in B10.M and B10.S mice, their F1 progeny and in backcrosses show that there are two codominantly expressed alleles at a single locus regulating the serum concentration. Measurements of the 40 000 dalton chain in recombinant mice suggest that the controlling locus is situated to the right of the S region.

AB - Mouse serum contains a protein complex consisting of at least three polypeptide chains. One of the chains with an approximate molecular weight of 40 000 is similar to the heavy chain of normal H-2 antigens. The serum concentration of this 40 000 dalton chain is under genetic control. Formal genetic analyses in B10.M and B10.S mice, their F1 progeny and in backcrosses show that there are two codominantly expressed alleles at a single locus regulating the serum concentration. Measurements of the 40 000 dalton chain in recombinant mice suggest that the controlling locus is situated to the right of the S region.

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Genetic control of the serum concentration of an H-2-antigen-like polypeptide chain

Abstract

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