TY - CHAP
T1 - Genetic targets in pediatric acute lymphoblastic leukemia
AU - Gowda, Chandrika
AU - Dovat, Sinisa
N1 - Funding Information:
This work was supported in part by an R01 HL095120 grant, The Four Diamonds Fund of the Pennsylvania State University College of Medicine, John Wawrynovic Leukemia Research Scholar Endowment (SD), St.Baldrick’s foundation grant.
PY - 2013
Y1 - 2013
N2 - Acute leukemia represents 31% of all cancers diagnosed in children and 80% of it is of Lymphoblastic type. Multiple genetic lesions in the hematopoietic progenitor cells prior to or during differentiation to B and T cell lead to development of leukemia. There are several subtypes of Acute Leukemia based on chromosome number changes, the presence of certain translocations and gene mutations, each of which has different clinical, biological and prognostic features. High throughput genomic technologies like array-based comparative genomic hybridization (array-CGH) and single nucleotide polymorphism microarrays (SNP arrays), have given us insight through a very detailed look at the genetic changes of leukemia, specifically, ALL. Here, we discuss various genetic mutations identified in Acute Lymphoblastic Leukemia. We also explore various genetic targets and currently available as well as upcoming targeted therapies for ALL.
AB - Acute leukemia represents 31% of all cancers diagnosed in children and 80% of it is of Lymphoblastic type. Multiple genetic lesions in the hematopoietic progenitor cells prior to or during differentiation to B and T cell lead to development of leukemia. There are several subtypes of Acute Leukemia based on chromosome number changes, the presence of certain translocations and gene mutations, each of which has different clinical, biological and prognostic features. High throughput genomic technologies like array-based comparative genomic hybridization (array-CGH) and single nucleotide polymorphism microarrays (SNP arrays), have given us insight through a very detailed look at the genetic changes of leukemia, specifically, ALL. Here, we discuss various genetic mutations identified in Acute Lymphoblastic Leukemia. We also explore various genetic targets and currently available as well as upcoming targeted therapies for ALL.
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U2 - 10.1007/978-1-4614-6176-0_15
DO - 10.1007/978-1-4614-6176-0_15
M3 - Chapter
C2 - 23288647
AN - SCOPUS:84873577911
SN - 9781461461753
T3 - Advances in Experimental Medicine and Biology
SP - 327
EP - 340
BT - Impact of Genetic Targets on Cancer Therapy
PB - Springer Science and Business Media, LLC
ER -