@article{24923ca128d248f7a69c3a8c5f365a37,
title = "Genome-wide association studies in diverse populations",
abstract = "Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.",
author = "Rosenberg, {Noah A.} and Lucy Huang and Jewett, {Ethan M.} and Szpiech, {Zachary A.} and Ivana Jankovic and Michael Boehnke",
note = "Funding Information: We thank L. Hindorff for detailed information on the National Human Genome Research Institute (NHGRI) catalogue of GWA studies, the DIAGRAM Consortium for use of prepublication data, J. Li and S. Z{\"o}llner for helpful discussions, and N. Patterson and an anonymous reviewer for comments on a draft of the manuscript. We are grateful to M. DeGiorgio, M. Jakobsson, S. Reddy and P. Scheet for assistance with Box 1 and with figure preparation. Support was provided by US National Institutes of Health grants DK062370, GM081441, HG000376 and HL090564, and by grants from the Burroughs Wellcome Fund and the Alfred P. Sloan Foundation.",
year = "2010",
month = may,
doi = "10.1038/nrg2760",
language = "English (US)",
volume = "11",
pages = "356--366",
journal = "Nature Reviews Genetics",
issn = "1471-0056",
publisher = "Nature Research",
number = "5",
}
