Genome-wide association studies in diverse populations

Noah A. Rosenberg, Lucy Huang, Ethan M. Jewett, Zachary A. Szpiech, Ivana Jankovic, Michael Boehnke

Research output: Contribution to journalReview articlepeer-review

443 Scopus citations


Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.

Original languageEnglish (US)
Pages (from-to)356-366
Number of pages11
JournalNature Reviews Genetics
Issue number5
StatePublished - May 2010

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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