@article{65f10bbb86244238a770d6c31e6c79c6,
title = "Genome-wide linkage analysis of pulse pressure in American Indians: The strong heart study",
abstract = "Background: Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. Methods: To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SHFS). Blood pressure was measured three times and the average of the last two measures was used for analyses. Pulse pressure, the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), was log-transformed and adjusted for the effects of age and sex within each study center. Variance component linkage analyses were performed using marker allele frequencies derived from all individuals and multipoint identity-by-descent matrices calculated in Loki. Results: We identified a quantitative-trait locus influencing pulse pressure on chromosome 7 at 37 cM (marker D7S493, LOD = 3.3) and suggestive evidence of linkage on chromosome 19 at 92 cM (marker D19S888, LOD = 1.8). Conclusions: The signal on 7p15.3 overlaps positive findings for pulse pressure among Utah population samples, suggesting that this region may harbor gene variants for blood pressure related traits.",
author = "Nora Franceschini and MacCluer, {Jean W.} and Rose, {Kathreen M.} and Sue Rutherford and Cole, {Shelley A.} and Sandy Laston and G{\"o}ring, {Harald H.H.} and Diego, {Vincent P.} and Roman, {Mary J.} and Lee, {Elisa T.} and Best, {Lyle G.} and Howard, {Barbara V.} and Fabsitz, {Richard R.} and North, {Kari E.}",
note = "Funding Information: acknowledgments: We thank the Strong Heart Family Study participants. In addition, the cooperation of the Indian Health Service hospitals and clinics, and directors of the SHS clinics, and the many collaborators and staff of the Strong Heart Study have made this project possible. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Indian Health Service. This study has been presented in part at the 2006 International Genetic epidemiology Meeting, November 16–17, 2006, St Pete{\textquoteright}s, FL, uSa. This research was funded by a cooperative agreement that includes grants u01 HL65520, u01 HL41642, u01 HL41652, u01 HL41654, and u01 HL65521 from the National Heart, Lung, and blood Institute. Development of SOLar and the methods implemented in it are supported by uS Public Health Service grant MH059490 from the National Institutes of Health. Dr Franceschini is supported by the american Heart association award.",
year = "2008",
month = feb,
doi = "10.1038/ajh.2007.34",
language = "English (US)",
volume = "21",
pages = "194--199",
journal = "American journal of hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "2",
}