TY - JOUR
T1 - Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers
T2 - Implications to emergence and its zoonotic potential towards public health
AU - Shabbir, Muhammad Zubair
AU - Nissly, Ruth Helmus
AU - Ahad, Abdul
AU - Rabbani, Masood
AU - Lim, Levina
AU - Chothe, Shubhada K.
AU - Subbiah, Murugan
AU - Sebastian, Aswathy
AU - Albert, Istvan
AU - Ul-Rahman, Aziz
AU - Jayarao, Bhushan M.
AU - Kuchipudi, Suresh V.
N1 - Publisher Copyright:
© 2021 Wolters Kluwer Medknow Publications. All rights reserved.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Objective: To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1 (AOAV-1) isolates from poultry workers with respiratory symptoms. Methods: Using Illumina MiSeq, whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates. A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools. Results: Phylogenetic analysis and genetic distance estimation suggested a close relationship among human- and avian-originated velogenic strains of genotype XIII, sub-genotype XIII.2.1. Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains. Conclusions: To our knowledge, this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract. Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.
AB - Objective: To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1 (AOAV-1) isolates from poultry workers with respiratory symptoms. Methods: Using Illumina MiSeq, whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates. A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools. Results: Phylogenetic analysis and genetic distance estimation suggested a close relationship among human- and avian-originated velogenic strains of genotype XIII, sub-genotype XIII.2.1. Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains. Conclusions: To our knowledge, this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract. Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.
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U2 - 10.4103/1995-7645.306762
DO - 10.4103/1995-7645.306762
M3 - Article
AN - SCOPUS:85100024665
SN - 1995-7645
VL - 14
SP - 64
EP - 72
JO - Asian Pacific Journal of Tropical Medicine
JF - Asian Pacific Journal of Tropical Medicine
IS - 2
ER -