Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae

David J. Galgoczy; Ann Cassidy-Stone; Manuel Llinás; Sean M. O'Rourke; Ira Herskowitz; Joseph L. DeRisi; Alexander D. Johnson

doi:10.1073/pnas.0407611102

Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae

David J. Galgoczy
, Ann Cassidy-Stone
, Manuel Llinás
, Sean M. O'Rourke
, Ira Herskowitz
, Joseph L. DeRisi
, Alexander D. Johnson

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

The budding yeast Saccharomyces cerevisiae has three cell types (a cells, a cells, and a/a cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S. cerevisiae. We believe this work represents a complete description of cell-type specification in a eukaryote.

Original language	English (US)
Pages (from-to)	18069-18074
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	101
Issue number	52
DOIs	https://doi.org/10.1073/pnas.0407611102
State	Published - Dec 28 2004

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title = "Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae",

abstract = "The budding yeast Saccharomyces cerevisiae has three cell types (a cells, a cells, and a/a cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S. cerevisiae. We believe this work represents a complete description of cell-type specification in a eukaryote.",

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T1 - Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae

AU - Galgoczy, David J.

AU - Cassidy-Stone, Ann

AU - Llinás, Manuel

AU - O'Rourke, Sean M.

AU - Herskowitz, Ira

AU - DeRisi, Joseph L.

AU - Johnson, Alexander D.

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N2 - The budding yeast Saccharomyces cerevisiae has three cell types (a cells, a cells, and a/a cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S. cerevisiae. We believe this work represents a complete description of cell-type specification in a eukaryote.

AB - The budding yeast Saccharomyces cerevisiae has three cell types (a cells, a cells, and a/a cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S. cerevisiae. We believe this work represents a complete description of cell-type specification in a eukaryote.

UR - https://www.scopus.com/pages/publications/11144221718

UR - https://www.scopus.com/pages/publications/11144221718#tab=citedBy

U2 - 10.1073/pnas.0407611102

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AN - SCOPUS:11144221718

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SP - 18069

EP - 18074

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 52

ER -

Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae

Abstract

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