TY - JOUR
T1 - Genomic features of lactic acid bacteria effecting bioprocessing and health
AU - Klaenhammer, Todd R.
AU - Barrangou, Rodolphe
AU - Buck, B. Logan
AU - Azcarate-Peril, M. Andrea
AU - Altermann, Eric
N1 - Funding Information:
The substantial contributions of many individuals participating in this work in our laboratory and as collaborators are gratefully acknowledged. Support for the LAB genetics and Functional Genomics programs has been provided through the North Carolina Agricultural Research Service, the North Carolina Dairy Foundation, Danisco, Inc., Dairy Management, Inc., the Southeast Dairy Foods Research Center, the California Dairy Research Foundation, the NIH Biotechnology Program, GAANN Fellowships in Biotechnology, IGERT Genomics Fellowships, and the USDA National Research Initiative Competitive Grants Program. Our special gratitude is expressed to Evelyn Durmaz, Rosemary Sanozky-Dawes, and Edwina Kleeman for many years of laboratory management and excellent research, to the US Department of Energy Joint Genome Institute for draft sequencing, the members of the U.S. Lactic Acid Bacteria Genomics Consortium (LABGC) for genome information and analysis, and to Fidelity Systems, Inc., for sequencing efforts to close and complete selected genomes used in these analyses. Thanks are also extended to A. Mercenier, W. de Vos, T. Shinoda, M. Saier, D.A. Mills, K. Makarova, and E. Koonin for providing data and/or preprints prior to publication.
PY - 2005/8
Y1 - 2005/8
N2 - The lactic acid bacteria are a functionally related group of organisms known primarily for their bioprocessing roles in food and beverages. More recently, selected members of the lactic acid bacteria have been implicated in a number of probiotic roles that impact general health and well-being. Genomic analyses of multiple members of the lactic acid bacteria, at the genus, species, and strain level, have now elucidated many genetic features that direct their fermentative and probiotic roles. This information is providing an important platform for understanding core mechanisms that control and regulate bacterial growth, survival, signaling, and fermentative processes and, in some cases, potentially underlying probiotic activities within complex microbial and host ecosystems.
AB - The lactic acid bacteria are a functionally related group of organisms known primarily for their bioprocessing roles in food and beverages. More recently, selected members of the lactic acid bacteria have been implicated in a number of probiotic roles that impact general health and well-being. Genomic analyses of multiple members of the lactic acid bacteria, at the genus, species, and strain level, have now elucidated many genetic features that direct their fermentative and probiotic roles. This information is providing an important platform for understanding core mechanisms that control and regulate bacterial growth, survival, signaling, and fermentative processes and, in some cases, potentially underlying probiotic activities within complex microbial and host ecosystems.
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U2 - 10.1016/j.femsre.2005.04.007
DO - 10.1016/j.femsre.2005.04.007
M3 - Review article
C2 - 15964092
AN - SCOPUS:23944518601
SN - 0168-6445
VL - 29
SP - 393
EP - 409
JO - FEMS Microbiology Reviews
JF - FEMS Microbiology Reviews
IS - 3 SPEC. ISS.
ER -