Gestational diabetes insipidus: From presentation to resolution: A report of 2 cases

Malini D. Persad, Xiannian Wu, Jennie Ou, J. Gerald Quirk, David J. Garry

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Gestational diabetes insipidus is a rare endocrinopathy caused by elevated levels of vaso-pressinase, with a paucity of cases described in the obstetrics literature. CASE: We present 2 cases of women who presented in the third trimester of pregnancy with complaints of severe polydipsia, polyuria, and nocturia. Maternal laboratory work was remarkable for decreased urine osmolality and increased serum osmolality. Both patients were effectively treated with desmopressin, which improved maternal symptoms. Both women had resolution of the diabetes insipidus in the postpartum period. CONCLUSION: While rare, early recognition and management of gestational diabetes insipidus can avert potential maternal and fetal harm.

Original languageEnglish (US)
Pages (from-to)527-529
Number of pages3
JournalJournal of Reproductive Medicine
Issue number6
StatePublished - Dec 2018

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology


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