Gestational diabetes insipidus: From presentation to resolution: A report of 2 cases

Malini D. Persad; Xiannian Wu; Jennie Ou; J. Gerald Quirk; David J. Garry

Gestational diabetes insipidus: From presentation to resolution: A report of 2 cases

Malini D. Persad, Xiannian Wu, Jennie Ou, J. Gerald Quirk, David J. Garry

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Gestational diabetes insipidus is a rare endocrinopathy caused by elevated levels of vaso-pressinase, with a paucity of cases described in the obstetrics literature. CASE: We present 2 cases of women who presented in the third trimester of pregnancy with complaints of severe polydipsia, polyuria, and nocturia. Maternal laboratory work was remarkable for decreased urine osmolality and increased serum osmolality. Both patients were effectively treated with desmopressin, which improved maternal symptoms. Both women had resolution of the diabetes insipidus in the postpartum period. CONCLUSION: While rare, early recognition and management of gestational diabetes insipidus can avert potential maternal and fetal harm.

Original language	English (US)
Pages (from-to)	527-529
Number of pages	3
Journal	Journal of Reproductive Medicine
Volume	63
Issue number	6
State	Published - Dec 2018

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynecology

Cite this

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title = "Gestational diabetes insipidus: From presentation to resolution: A report of 2 cases",

abstract = "BACKGROUND: Gestational diabetes insipidus is a rare endocrinopathy caused by elevated levels of vaso-pressinase, with a paucity of cases described in the obstetrics literature. CASE: We present 2 cases of women who presented in the third trimester of pregnancy with complaints of severe polydipsia, polyuria, and nocturia. Maternal laboratory work was remarkable for decreased urine osmolality and increased serum osmolality. Both patients were effectively treated with desmopressin, which improved maternal symptoms. Both women had resolution of the diabetes insipidus in the postpartum period. CONCLUSION: While rare, early recognition and management of gestational diabetes insipidus can avert potential maternal and fetal harm.",

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AU - Persad, Malini D.

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AU - Gerald Quirk, J.

AU - Garry, David J.

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N2 - BACKGROUND: Gestational diabetes insipidus is a rare endocrinopathy caused by elevated levels of vaso-pressinase, with a paucity of cases described in the obstetrics literature. CASE: We present 2 cases of women who presented in the third trimester of pregnancy with complaints of severe polydipsia, polyuria, and nocturia. Maternal laboratory work was remarkable for decreased urine osmolality and increased serum osmolality. Both patients were effectively treated with desmopressin, which improved maternal symptoms. Both women had resolution of the diabetes insipidus in the postpartum period. CONCLUSION: While rare, early recognition and management of gestational diabetes insipidus can avert potential maternal and fetal harm.

AB - BACKGROUND: Gestational diabetes insipidus is a rare endocrinopathy caused by elevated levels of vaso-pressinase, with a paucity of cases described in the obstetrics literature. CASE: We present 2 cases of women who presented in the third trimester of pregnancy with complaints of severe polydipsia, polyuria, and nocturia. Maternal laboratory work was remarkable for decreased urine osmolality and increased serum osmolality. Both patients were effectively treated with desmopressin, which improved maternal symptoms. Both women had resolution of the diabetes insipidus in the postpartum period. CONCLUSION: While rare, early recognition and management of gestational diabetes insipidus can avert potential maternal and fetal harm.

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Gestational diabetes insipidus: From presentation to resolution: A report of 2 cases

Abstract

All Science Journal Classification (ASJC) codes

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