TY - JOUR
T1 - Ghrelin and peptide YY increase with weight loss during a 12-month intervention to reduce dietary energy density in obese women
AU - Hill, Brenna R.
AU - Rolls, Barbara J.
AU - Roe, Liane S.
AU - De Souza, Mary Jane
AU - Williams, Nancy I.
N1 - Funding Information:
We thank Julie Ello-Martin, the staff in the Laboratory for the Study of Human Ingestive Behavior at The Pennsylvania State University and the participants for their contributions. Brenna R. Hill is supported by Pennsylvania State University's Intercollegiate Graduate Degree Program in Physiology. The clinical trial was funded by NIH grants R37DK039177 and M01RR10732 . The current study was also supported by NIH grants M01 RR 10732 and US DoD PR054531 .
PY - 2013
Y1 - 2013
N2 - Reducing dietary energy density (ED) promotes weight loss; however, underlying mechanisms are not well understood. The purpose of this study was to determine if low-ED diets facilitate weight loss through actions on ghrelin and peptide YY (PYY), independent of influences of psychosocial measures. Seventy-one obese women (BMI 30-40 kg/m2) ages 22-60 years received counseling to reduce ED. Fasting blood samples were analyzed for total ghrelin and total PYY by radioimmunoassay at months 0, 3, 6, and 12. Restraint, disinhibition, and hunger were assessed by the Eating Inventory. Body weight (-7.8 ± 0.5 kg), BMI (-2.9 ± 0.2 kg/m2), body fat (-3.0 ± 0.3%), and ED (-0.47 ± 0.05 kcal/g or -1.97 ± 0.21 kJ/g) decreased from months 0 to 6 (p < 0.05) after which no change occurred from months 6 to 12. Ghrelin increased in a curvilinear fashion (month 0: 973 ± 39, month 3: 1024 ± 37, month 6: 1109 ± 44, and month 12: 1063 ± 45 pg/ml, p < 0.001) and PYY increased linearly (month 0: 74.2 ± 3.1, month 3: 76.4 ± 3.2, month 6: 77.2 ± 3.0, month 12: 82.8 ± 3.2 pg/ml, p < 0.001). ED, body weight, and hunger predicted ghrelin, with ED being the strongest predictor (ghrelin = 2674.8 + 291.6 × ED - 19.2 × BW - 15 × H; p < 0.05). There was a trend toward a significant association between ED and PYY (PYY = 115.0 - 43.1 × ED; p = 0.05). Reductions in ED may promote weight loss and weight loss maintenance by opposing increases in ghrelin and promoting increases in PYY.
AB - Reducing dietary energy density (ED) promotes weight loss; however, underlying mechanisms are not well understood. The purpose of this study was to determine if low-ED diets facilitate weight loss through actions on ghrelin and peptide YY (PYY), independent of influences of psychosocial measures. Seventy-one obese women (BMI 30-40 kg/m2) ages 22-60 years received counseling to reduce ED. Fasting blood samples were analyzed for total ghrelin and total PYY by radioimmunoassay at months 0, 3, 6, and 12. Restraint, disinhibition, and hunger were assessed by the Eating Inventory. Body weight (-7.8 ± 0.5 kg), BMI (-2.9 ± 0.2 kg/m2), body fat (-3.0 ± 0.3%), and ED (-0.47 ± 0.05 kcal/g or -1.97 ± 0.21 kJ/g) decreased from months 0 to 6 (p < 0.05) after which no change occurred from months 6 to 12. Ghrelin increased in a curvilinear fashion (month 0: 973 ± 39, month 3: 1024 ± 37, month 6: 1109 ± 44, and month 12: 1063 ± 45 pg/ml, p < 0.001) and PYY increased linearly (month 0: 74.2 ± 3.1, month 3: 76.4 ± 3.2, month 6: 77.2 ± 3.0, month 12: 82.8 ± 3.2 pg/ml, p < 0.001). ED, body weight, and hunger predicted ghrelin, with ED being the strongest predictor (ghrelin = 2674.8 + 291.6 × ED - 19.2 × BW - 15 × H; p < 0.05). There was a trend toward a significant association between ED and PYY (PYY = 115.0 - 43.1 × ED; p = 0.05). Reductions in ED may promote weight loss and weight loss maintenance by opposing increases in ghrelin and promoting increases in PYY.
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U2 - 10.1016/j.peptides.2013.09.009
DO - 10.1016/j.peptides.2013.09.009
M3 - Article
C2 - 24076434
AN - SCOPUS:84885365581
SN - 0196-9781
VL - 49
SP - 138
EP - 144
JO - Peptides
JF - Peptides
ER -