Glioblastoma stem-like cells-biology and therapeutic implications

Demirkan B. Gürsel; Benjamin J. Shin; Jan Karl Burkhardt; Kartik Kesavabhotla; Cody D. Schlaff; John A. Boockvar

doi:10.3390/cancers3022655

Glioblastoma stem-like cells-biology and therapeutic implications

Demirkan B. Gürsel, Benjamin J. Shin, Jan Karl Burkhardt, Kartik Kesavabhotla, Cody D. Schlaff, John A. Boockvar

Department of Radiology

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) from patient-derived GBM tissue samples. The hallmarks of TSCs are that they must be able to self-renew and retain tumorigenicity. The isolation, optimization and derivation of TSCs as outlined in this review, will be important in understanding biology and therapeutic applications related to these cells.

Original language	English (US)
Pages (from-to)	2655-2666
Number of pages	12
Journal	Cancers
Volume	3
Issue number	2
DOIs	https://doi.org/10.3390/cancers3022655
State	Published - Jun 2011

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.3390/cancers3022655

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title = "Glioblastoma stem-like cells-biology and therapeutic implications",

abstract = "The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) from patient-derived GBM tissue samples. The hallmarks of TSCs are that they must be able to self-renew and retain tumorigenicity. The isolation, optimization and derivation of TSCs as outlined in this review, will be important in understanding biology and therapeutic applications related to these cells.",

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AU - Gürsel, Demirkan B.

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AU - Burkhardt, Jan Karl

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AU - Schlaff, Cody D.

AU - Boockvar, John A.

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AB - The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) from patient-derived GBM tissue samples. The hallmarks of TSCs are that they must be able to self-renew and retain tumorigenicity. The isolation, optimization and derivation of TSCs as outlined in this review, will be important in understanding biology and therapeutic applications related to these cells.

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Glioblastoma stem-like cells-biology and therapeutic implications

Abstract

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