Glucagon-dependent suppression of mTORC1 is associated with upregulation of hepatic FGF21 mRNA translation

Biochemistry, Genetics and Molecular Biology

• Mechanistic Target of Rapamycin 100%
• Upregulation 100%
• RNA Translation 100%
• FGF21 100%
• Downregulation 11%
• Hepatocyte 11%
• Protein Expression 5%
• Secretion (Process) 5%
• Primary Culture 5%
• Insulin Sensitivity 5%
• Peptide Hormone 5%

Keyphrases

• Glucagon 100%
• Fibroblast Growth Factor 21 (FGF21) 100%
• Mammalian Target of Rapamycin (mTOR) 100%
• MRNA Abundance 16%
• Liver 11%
• High-fat Diet 5%
• Rapamycin 5%
• Protein Expression 5%
• Rat Hepatocytes 5%
• Hepatocytes 5%
• Primary Culture 5%
• Insulin Sensitivity 5%
• Culture Media 5%
• Hepatoma Cells 5%
• HepG2 5%
• Refeeding 5%
• Metabolic Defects 5%
• Peptide Hormone 5%