Glyceryl Polyphosphazenes: Synthesis, Properties, and Hydrolysis

Harry R. Allcock; Sukky Kwon

doi:10.1021/ma00185a015

Glyceryl Polyphosphazenes: Synthesis, Properties, and Hydrolysis

Harry R. Allcock, Sukky Kwon

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Abstract

Methylene-, isopropylidene-, and methoxymethylene-protected glyceryl units have been linked to cyclic and high polymeric phosphazenes. The structures and physical properties of these protected glyceryl-substituted phosphazenes were investigated by ³¹P NMR, NMR, and IR spectroscopy and thermal analysis. Hydrolytic deprotection reactions in acidic media yielded the water-soluble cyclic trimeric and high polymeric glycerylphosphazenes. Cross-linking of the protected high polymers was accomplished by 7 irradiation. The deprotected polymer cross-linked in the presence of adipoyl chloride or hexamethylene diisocyanate to yield systems that absorbed water to form hydrogels. Slow hydrolysis of poly(diglycerophosphazene) occurred in neutral aqueous media at 37 °C to yield glycerol, phosphoric acid, and ammonia.

Original language	English (US)
Pages (from-to)	1980-1985
Number of pages	6
Journal	Macromolecules
Volume	21
Issue number	7
DOIs	https://doi.org/10.1021/ma00185a015
State	Published - Jul 1988

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/ma00185a015

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title = "Glyceryl Polyphosphazenes: Synthesis, Properties, and Hydrolysis",

abstract = "Methylene-, isopropylidene-, and methoxymethylene-protected glyceryl units have been linked to cyclic and high polymeric phosphazenes. The structures and physical properties of these protected glyceryl-substituted phosphazenes were investigated by 31P NMR, NMR, and IR spectroscopy and thermal analysis. Hydrolytic deprotection reactions in acidic media yielded the water-soluble cyclic trimeric and high polymeric glycerylphosphazenes. Cross-linking of the protected high polymers was accomplished by 7 irradiation. The deprotected polymer cross-linked in the presence of adipoyl chloride or hexamethylene diisocyanate to yield systems that absorbed water to form hydrogels. Slow hydrolysis of poly(diglycerophosphazene) occurred in neutral aqueous media at 37 °C to yield glycerol, phosphoric acid, and ammonia.",

author = "Allcock, {Harry R.} and Sukky Kwon",

year = "1988",

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doi = "10.1021/ma00185a015",

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T1 - Glyceryl Polyphosphazenes

T2 - Synthesis, Properties, and Hydrolysis

AU - Allcock, Harry R.

AU - Kwon, Sukky

PY - 1988/7

Y1 - 1988/7

N2 - Methylene-, isopropylidene-, and methoxymethylene-protected glyceryl units have been linked to cyclic and high polymeric phosphazenes. The structures and physical properties of these protected glyceryl-substituted phosphazenes were investigated by 31P NMR, NMR, and IR spectroscopy and thermal analysis. Hydrolytic deprotection reactions in acidic media yielded the water-soluble cyclic trimeric and high polymeric glycerylphosphazenes. Cross-linking of the protected high polymers was accomplished by 7 irradiation. The deprotected polymer cross-linked in the presence of adipoyl chloride or hexamethylene diisocyanate to yield systems that absorbed water to form hydrogels. Slow hydrolysis of poly(diglycerophosphazene) occurred in neutral aqueous media at 37 °C to yield glycerol, phosphoric acid, and ammonia.

AB - Methylene-, isopropylidene-, and methoxymethylene-protected glyceryl units have been linked to cyclic and high polymeric phosphazenes. The structures and physical properties of these protected glyceryl-substituted phosphazenes were investigated by 31P NMR, NMR, and IR spectroscopy and thermal analysis. Hydrolytic deprotection reactions in acidic media yielded the water-soluble cyclic trimeric and high polymeric glycerylphosphazenes. Cross-linking of the protected high polymers was accomplished by 7 irradiation. The deprotected polymer cross-linked in the presence of adipoyl chloride or hexamethylene diisocyanate to yield systems that absorbed water to form hydrogels. Slow hydrolysis of poly(diglycerophosphazene) occurred in neutral aqueous media at 37 °C to yield glycerol, phosphoric acid, and ammonia.

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U2 - 10.1021/ma00185a015

DO - 10.1021/ma00185a015

M3 - Article

AN - SCOPUS:0024051297

SN - 0024-9297

VL - 21

SP - 1980

EP - 1985

JO - Macromolecules

JF - Macromolecules

IS - 7

ER -

Glyceryl Polyphosphazenes: Synthesis, Properties, and Hydrolysis

Abstract

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