Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

Keyphrases

• Cell Proliferation 100%
• Tumorigenicity 100%
• Neuroblastoma Cells 100%
• Glycine Decarboxylase 100%
• Transcriptional Targets 100%
• Knockdown 20%
• High-risk Neuroblastoma 20%
• MYCN-amplified Neuroblastoma 20%
• Purine 10%
• Steady State 10%
• Functional Significance 10%
• Rate-limiting Step 10%
• Fatty Acids 10%
• Citrate 10%
• Cholesterol 10%
• Neuroblastoma Cell Line 10%
• Growth Inhibition 10%
• RNA Interference 10%
• Oncogene 10%
• G1 Arrest 10%
• Glycine 10%
• Cholesterol Synthesis 10%
• Metabolic Profiling 10%
• Poor Prognosis 10%
• Central Carbon Metabolism 10%
• Therapeutic Strategies 10%
• Whole Genome Amplification 10%
• One-carbon Units 10%
• 5-methyltetrahydrofolate 10%
• Pediatric Cancer 10%
• Metabolic Vulnerability 10%
• Purine Synthesis 10%
• Neuroblastoma Tumor 10%
• MYCN Amplification 10%

Medicine and Dentistry

• Cell Proliferation 100%
• Carcinogenicity 100%
• Neuroblastoma Cell 100%
• Glycine Dehydrogenase (Decarboxylating) 100%
• Ganglioneuroblastoma 30%
• Metabolomics 10%
• Biological Marker 10%
• Cell Line 10%
• Neoplasm 10%
• Fatty Acid 10%
• Purine 10%
• Neuroblastoma Cell Line 10%
• Upregulation 10%
• Steady State 10%
• Oncogene 10%
• G1/S Transition 10%
• Pediatric Cancer 10%
• Cholesterol Synthesis 10%
• Carbon Metabolism 10%
• RNAI 10%

Biochemistry, Genetics and Molecular Biology

• Cell Proliferation 100%
• Carboxy-Lyases 100%
• Metabolomics 10%
• Steady State 10%
• Oncogene 10%
• G1/S Transition 10%
• Upregulation 10%
• Cholesterol Synthesis 10%
• Purine Synthesis 10%
• Carbon Metabolism 10%
• Genomics 10%
• RNAI 10%
• 5,10-Methylenetetrahydrofolate 10%