TY - JOUR
T1 - Glycoconjugates
T2 - Roles in neural diseases caused by exogenous pathogens
AU - Schengrund, Cara Lynne
PY - 2006/8
Y1 - 2006/8
N2 - Numerous reports indicate that lipid or protein associated carbohydrates are essential for infection of cells by various viruses, bacteria, or bacterial toxins, some of which affect the nervous system. Examples of such pathogens include tetanus and botulinum neurotoxin, Shiga and Shiga-like toxins, Borrelia burgdorferi, Mycobacterium leprae, and human immunodeficiency virus. This review discusses evidence indicating that carbohydrates are essential for these pathogens to induce their deleterious effects, the putative function of the carbohydrates, and how this knowledge might be used to combat the effects of the pathogen.
AB - Numerous reports indicate that lipid or protein associated carbohydrates are essential for infection of cells by various viruses, bacteria, or bacterial toxins, some of which affect the nervous system. Examples of such pathogens include tetanus and botulinum neurotoxin, Shiga and Shiga-like toxins, Borrelia burgdorferi, Mycobacterium leprae, and human immunodeficiency virus. This review discusses evidence indicating that carbohydrates are essential for these pathogens to induce their deleterious effects, the putative function of the carbohydrates, and how this knowledge might be used to combat the effects of the pathogen.
UR - http://www.scopus.com/inward/record.url?scp=33746954522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746954522&partnerID=8YFLogxK
U2 - 10.2174/187152706777950701
DO - 10.2174/187152706777950701
M3 - Review article
C2 - 16918390
AN - SCOPUS:33746954522
SN - 1871-5273
VL - 5
SP - 381
EP - 389
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 4
ER -
