TY - JOUR
T1 - GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells
AU - Greter, Melanie
AU - Helft, Julie
AU - Chow, Andrew
AU - Hashimoto, Daigo
AU - Mortha, Arthur
AU - Agudo-Cantero, Judith
AU - Bogunovic, Milena
AU - Gautier, Emmanuel L.
AU - Miller, Jennifer
AU - Leboeuf, Marylene
AU - Lu, Geming
AU - Aloman, Costica
AU - Brown, Brian D.
AU - Pollard, Jeffrey W.
AU - Xiong, Huabao
AU - Randolph, Gwendalyn J.
AU - Chipuk, Jerry E.
AU - Frenette, Paul S.
AU - Merad, Miriam
N1 - Funding Information:
We would like to thank B. Becher for critical discussions. B.D.B. is supported by JDRF172010770 and DP2DK083052-01. J.E.C. is supported by NIH CA157740 and 5-FY11-74 grant from the March of Dimes Foundation. E.L.G. is supported by American Heart Association Postdoctoral Fellowship (Founder's Affiliate). H.X. is supported by NIH R56AI091871 and the Eli and Edythe L. Broad Foundation. G.J.R. is supported by AI049653. J.W.P. is supported by R01 CA131270 and P01 CA100324. M.B. is supported by a career development award from the Crohn's and Colitis Foundation of America and a primary caregiver technical assistance supplement from the National Institute of Allergy and Infectious Diseases. M.G. is supported by the National Science Foundation of Switzerland. M.M. is supported by the National Institutes of Health grants HL086899, AI095611, and CA154947. P.S.F. is supported by HL69438, DK056638, HL097819, and HL097700.
PY - 2012/6/29
Y1 - 2012/6/29
N2 - GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and resident CD103+ DCs in some tissues. Here we showed that in contrast to the current understanding, Csf-2 receptor acts in the steady state to promote the survival and homeostasis of nonlymphoid tissue-resident CD103+ and CD11b+ DCs. Absence of Csf-2 receptor on lung DCs abrogated the induction of CD8+ T cell immunity after immunization with particulate antigens. In contrast, Csf-2 receptor was dispensable for the differentiation and innate function of inflammatory DCs during acute injuries. Instead, inflammatory DCs required Csf-1 receptor for their development. Thus, Csf-2 is important in vaccine-induced CD8+ T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
AB - GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and resident CD103+ DCs in some tissues. Here we showed that in contrast to the current understanding, Csf-2 receptor acts in the steady state to promote the survival and homeostasis of nonlymphoid tissue-resident CD103+ and CD11b+ DCs. Absence of Csf-2 receptor on lung DCs abrogated the induction of CD8+ T cell immunity after immunization with particulate antigens. In contrast, Csf-2 receptor was dispensable for the differentiation and innate function of inflammatory DCs during acute injuries. Instead, inflammatory DCs required Csf-1 receptor for their development. Thus, Csf-2 is important in vaccine-induced CD8+ T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo.
UR - https://www.scopus.com/pages/publications/84863008117
UR - https://www.scopus.com/pages/publications/84863008117#tab=citedBy
U2 - 10.1016/j.immuni.2012.03.027
DO - 10.1016/j.immuni.2012.03.027
M3 - Article
C2 - 22749353
AN - SCOPUS:84863008117
SN - 1074-7613
VL - 36
SP - 1031
EP - 1046
JO - Immunity
JF - Immunity
IS - 6
ER -