Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia

Lawrence Aguis; Maria Hadjiconstantinou; Zan Xi Qu; Norton H. Neff; Dennis K. Pearl; Allan J. Yates

doi:10.1016/0736-5748(94)90014-0

Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia

Lawrence Aguis, Maria Hadjiconstantinou, Zan Xi Qu, Norton H. Neff, Dennis K. Pearl, Allan J. Yates

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4 Scopus citations

Abstract

Rat pups, seven days old, with right carotid artery ligations were exposed to an atmosphere of oxygen 8% remainder nitrogen for 2 hr. The animals that survived for three weeks after the hypoxic-ischemic episode had clusters of darkly stained (hematoxylin-eosin) neurons in the cortex and reduced uptake of dopamine (frontal cortex) and choline (frontal cortex, hippocampus and striatum) in preparations of synaptosomes. Treatment with GM1 ganglioside partially corrected the loss of uptake activity and increased the number of darkly stained neurons.

Original language	English (US)
Pages (from-to)	623-630
Number of pages	8
Journal	International Journal of Developmental Neuroscience
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/0736-5748(94)90014-0
State	Published - Nov 1994

All Science Journal Classification (ASJC) codes

Developmental Neuroscience
Developmental Biology

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@article{2dfcb789906d4cdba22533251fd6443c,

title = "Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia",

abstract = "Rat pups, seven days old, with right carotid artery ligations were exposed to an atmosphere of oxygen 8% remainder nitrogen for 2 hr. The animals that survived for three weeks after the hypoxic-ischemic episode had clusters of darkly stained (hematoxylin-eosin) neurons in the cortex and reduced uptake of dopamine (frontal cortex) and choline (frontal cortex, hippocampus and striatum) in preparations of synaptosomes. Treatment with GM1 ganglioside partially corrected the loss of uptake activity and increased the number of darkly stained neurons.",

author = "Lawrence Aguis and Maria Hadjiconstantinou and Qu, {Zan Xi} and Neff, {Norton H.} and Pearl, {Dennis K.} and Yates, {Allan J.}",

note = "Funding Information: Acknowledgements-The authors thank Mary Macone for excellent histological preparations, Dr Harold S. Weiss for helpful discussions and advice concerning the hypoxic chamber and Dr Michael Beattie for assistancew ith the morphometrics. This work was supported by a grant from NINDS no. NS 1016.5.",

year = "1994",

month = nov,

doi = "10.1016/0736-5748(94)90014-0",

language = "English (US)",

volume = "12",

pages = "623--630",

journal = "International Journal of Developmental Neuroscience",

issn = "0736-5748",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia

AU - Aguis, Lawrence

AU - Hadjiconstantinou, Maria

AU - Qu, Zan Xi

AU - Neff, Norton H.

AU - Pearl, Dennis K.

AU - Yates, Allan J.

N1 - Funding Information: Acknowledgements-The authors thank Mary Macone for excellent histological preparations, Dr Harold S. Weiss for helpful discussions and advice concerning the hypoxic chamber and Dr Michael Beattie for assistancew ith the morphometrics. This work was supported by a grant from NINDS no. NS 1016.5.

PY - 1994/11

Y1 - 1994/11

N2 - Rat pups, seven days old, with right carotid artery ligations were exposed to an atmosphere of oxygen 8% remainder nitrogen for 2 hr. The animals that survived for three weeks after the hypoxic-ischemic episode had clusters of darkly stained (hematoxylin-eosin) neurons in the cortex and reduced uptake of dopamine (frontal cortex) and choline (frontal cortex, hippocampus and striatum) in preparations of synaptosomes. Treatment with GM1 ganglioside partially corrected the loss of uptake activity and increased the number of darkly stained neurons.

AB - Rat pups, seven days old, with right carotid artery ligations were exposed to an atmosphere of oxygen 8% remainder nitrogen for 2 hr. The animals that survived for three weeks after the hypoxic-ischemic episode had clusters of darkly stained (hematoxylin-eosin) neurons in the cortex and reduced uptake of dopamine (frontal cortex) and choline (frontal cortex, hippocampus and striatum) in preparations of synaptosomes. Treatment with GM1 ganglioside partially corrected the loss of uptake activity and increased the number of darkly stained neurons.

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Gm1 ganglioside and darkly staining neurons in brains of rats subjected to neonatal hypoxia-ischemia

Abstract

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