GOAT links dietary lipids with the endocrine control of energy balance

Henriette Kirchner; Jesus A. Gutierrez; Patricia J. Solenberg; Paul T. Pfluger; Traci A. Czyzyk; Jill A. Willency; Annette Schürmann; Hans Georg Joost; Ronald J. Jandacek; John E. Hale; Mark L. Heiman; Matthias H. Tschöp

doi:10.1038/nm.1997

GOAT links dietary lipids with the endocrine control of energy balance

Henriette Kirchner, Jesus A. Gutierrez, Patricia J. Solenberg, Paul T. Pfluger, Traci A. Czyzyk, Jill A. Willency, Annette Schürmann, Hans Georg Joost, Ronald J. Jandacek, John E. Hale, Mark L. Heiman, Matthias H. Tschöp

Department of Anesthesiology and Perioperative Medicine

Research output: Contribution to journal › Article › peer-review

348 Scopus citations

Abstract

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

Original language	English (US)
Pages (from-to)	741-745
Number of pages	5
Journal	Nature Medicine
Volume	15
Issue number	7
DOIs	https://doi.org/10.1038/nm.1997
State	Published - Jul 2009

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm.1997

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@article{1e35d7dfa4f24cd3bfd1bf409f0fb326,

title = "GOAT links dietary lipids with the endocrine control of energy balance",

abstract = "Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.",

author = "Henriette Kirchner and Gutierrez, {Jesus A.} and Solenberg, {Patricia J.} and Pfluger, {Paul T.} and Czyzyk, {Traci A.} and Willency, {Jill A.} and Annette Sch{\"u}rmann and Joost, {Hans Georg} and Jandacek, {Ronald J.} and Hale, {John E.} and Heiman, {Mark L.} and Tsch{\"o}p, {Matthias H.}",

note = "Funding Information: We would like to thank J.E. Baker, B. Berger and J. Holland for their outstanding technical support. This manuscript was supported by the Leibniz Graduate College (H.K.) and by the US National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant R01-DK069987 (to M.H.T.).",

year = "2009",

month = jul,

doi = "10.1038/nm.1997",

language = "English (US)",

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T1 - GOAT links dietary lipids with the endocrine control of energy balance

AU - Kirchner, Henriette

AU - Gutierrez, Jesus A.

AU - Solenberg, Patricia J.

AU - Pfluger, Paul T.

AU - Czyzyk, Traci A.

AU - Willency, Jill A.

AU - Schürmann, Annette

AU - Joost, Hans Georg

AU - Jandacek, Ronald J.

AU - Hale, John E.

AU - Heiman, Mark L.

AU - Tschöp, Matthias H.

N1 - Funding Information: We would like to thank J.E. Baker, B. Berger and J. Holland for their outstanding technical support. This manuscript was supported by the Leibniz Graduate College (H.K.) and by the US National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant R01-DK069987 (to M.H.T.).

PY - 2009/7

Y1 - 2009/7

N2 - Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

AB - Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

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JF - Nature Medicine

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GOAT links dietary lipids with the endocrine control of energy balance

Abstract

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