GPI-anchored molecule-like protein (GML) expression in non-small cell lung cancer (NSCLC)

Takefumi Komiya, Tomonori Hirashima, Masanori Kikui, Masahiro Fukuoka, Atsuko Ohno, Ichiro Kawase

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: GPI-anchored molecule-like protein (GML) has been identified as a new target molecule of p53. In esophageal cancer cell lines, expression of GML mRNA, which was found to be significantly correlated with in vitro anti-cancer drug sensitivity, was observed only in the presence of wild-type p53. Materials and Methods: The relationship between expression of GML mRNA and p53 gene status in 24 non-small cell lung cancer (NSCLC) cell lines was examined using RT-PCR and PCR-SSCP followed by direct DNA sequencing. Results: Expression of GML mRNA was observed in only 3 of 24 cell lines. In contrast to previous studies showing p53-dependent GML expression, of the 3 cell lines expressing GML mRNA, one had a p53 gene mutation (codon 245: Gly to Cys). Conclusion: These findings suggest that the expression of GML mRNA is infrequent and regulated in a p53-independent manner in NSCLC.

Original languageEnglish (US)
Pages (from-to)4315-4319
Number of pages5
JournalAnticancer Research
Issue number5 B
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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