Granuloma annulare: An immunohistochemical study

Elizabeth Mullans, Klaus F. Helm

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The monocyte/histiocytic response in granuloma annulare has not been extensively studied. We studied the immunohistochemical staining pattern in granuloma annulare by using a panel of markers for “histiocytic” cells including Ham 56, KP1, factor XIIIa, Mac 387, vimentin, and lysozyme. The infiltrate failed to stain with the histiocytic markers, except with antibodies against vimentin and lysozyme. Commonly used histiocytic markers for infectious, immunogenic, and foreign body granulomas fail to stain the infiltrate in granuloma annulare. We hypothesize that a locally derived, immunologically distinct population of histiocytes produces the reaction pattern of granuloma annulare.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalJournal of Cutaneous Pathology
Issue number2
StatePublished - Apr 1994

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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