Granulomatous slack skin disease: A review, in comparison with mycosis fungoides

A. Shah, A. Safaya

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Granulomatous slack skin (GSS) is a rare cutaneous disorder characterized by the evolution of circumscribed erythematous loose skin masses, especially in the body folds, and histologically by a loss of elastic fibers and granulomatous T-cell infiltrates. This disease is often associated with preceding or successive lymphoproliferative malignancies, especially Mycosis Fungoides (MF) and Hodgkin's Disease (HD). Whether Granulomatous Slack Skin Disease is a benign disorder, an unusual host reaction or a precursor of malignant lymphoma or an indolent Cutaneous T-cell Lymphoma (CTCL) in itself, is still a controversy. This article reviews its literature on the etiology, clinical findings, and treatment of Granulomatous Slack Skin Disease. It also concentrates on its association with Hodgkin's disease and its comparison with Mycosis Fungoides and Sezary Syndrome.

Original languageEnglish (US)
Pages (from-to)1472-1478
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
Volume26
Issue number12
DOIs
StatePublished - Dec 2012

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

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