Growth and body composition in intrauterine growth retardation (IUGR) before and during human growth hormone administration

Peter A. Lee; Robert M. Blizzard; Donald B. Cheek; A. Barry Holt

doi:10.1016/0026-0495(74)90040-7

Growth and body composition in intrauterine growth retardation (IUGR) before and during human growth hormone administration

Peter A. Lee, Robert M. Blizzard, Donald B. Cheek, A. Barry Holt

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.

Original language	English (US)
Pages (from-to)	913-919
Number of pages	7
Journal	Metabolism
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/0026-0495(74)90040-7
State	Published - Oct 1974

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0026-0495(74)90040-7

Cite this

@article{d03bd253641b49268619e321cc80775f,

title = "Growth and body composition in intrauterine growth retardation (IUGR) before and during human growth hormone administration",

abstract = "The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.",

author = "Lee, {Peter A.} and Blizzard, {Robert M.} and Cheek, {Donald B.} and Holt, {A. Barry}",

note = "Funding Information: From rhe Department of Pediatrics, Johns Hopkins University and School of Medicine, Baltimore. Md. Received for publication January 5. 1974. Supported by NIH Grant HD-01852 and NIH Traineeship Grant TI-AM-5219. The patients were studied on the Pediatric Clinical Research Unit. supported by NIH Grant 5-MOI-RR-0052 from the General Clinical Research Centers Program of the Division of Research Resources. o 1974 by Grune & Stratton, Inc.",

year = "1974",

month = oct,

doi = "10.1016/0026-0495(74)90040-7",

language = "English (US)",

volume = "23",

pages = "913--919",

journal = "Metabolism",

issn = "0026-0495",

publisher = "W.B. Saunders",

number = "10",

}

TY - JOUR

T1 - Growth and body composition in intrauterine growth retardation (IUGR) before and during human growth hormone administration

AU - Lee, Peter A.

AU - Blizzard, Robert M.

AU - Cheek, Donald B.

AU - Holt, A. Barry

N1 - Funding Information: From rhe Department of Pediatrics, Johns Hopkins University and School of Medicine, Baltimore. Md. Received for publication January 5. 1974. Supported by NIH Grant HD-01852 and NIH Traineeship Grant TI-AM-5219. The patients were studied on the Pediatric Clinical Research Unit. supported by NIH Grant 5-MOI-RR-0052 from the General Clinical Research Centers Program of the Division of Research Resources. o 1974 by Grune & Stratton, Inc.

PY - 1974/10

Y1 - 1974/10

N2 - The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.

AB - The influence of exogenous HGH upon the size and number of muscle cells, nitrogen retention on a nitrogen balance study, and linear growth were evaluated in eight children with intrauterine growth retardation. Before treatment, these patients were all significantly short and had decreased muscle nuclear number for age. On HGH treatment, linear growth increased significantly over previous growth rates, nitrogen retention occurred, and the muscle cells responded with an increase in cell multiplication but without an increase in cell size. These children, therefore, were capable of response to HGH, since cell multiplication but not cytoplasmic growth are ascribed to HGH.

UR - http://www.scopus.com/inward/record.url?scp=0016277666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016277666&partnerID=8YFLogxK

U2 - 10.1016/0026-0495(74)90040-7

DO - 10.1016/0026-0495(74)90040-7

M3 - Article

C2 - 4370058

AN - SCOPUS:0016277666

SN - 0026-0495

VL - 23

SP - 913

EP - 919

JO - Metabolism

JF - Metabolism

IS - 10

ER -

Growth and body composition in intrauterine growth retardation (IUGR) before and during human growth hormone administration

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this