TY - GEN
T1 - Guidance system development for radial-probe endobronchial ultrasound bronchoscopy
AU - Zhao, Wennan
AU - Bascom, Rebecca
AU - Toth, Jennifer
AU - Higgins, William E.
N1 - Funding Information:
This work was funded by NIH NCI grant R01-CA151433. Dr. Higgins and Penn State have financial interests in Broncus Medical, Inc. These financial interests have been reviewed by the University’s Institutional and Individual Conflict of Interest Committees and are currently being managed by the University and reported to the NIH.
Publisher Copyright:
© 2019 SPIE.
PY - 2019
Y1 - 2019
N2 - For peripheral pulmonary lesion diagnosis, surgical thoracoscopy and percutaneous needle biopsy are common invasive options, but entail significant risks; e.g., percutaneous biopsy carries a 15% pneumothorax rate and risk of other complications. The development of new bronchoscopic devices, such as radial-probe endobronchial ultrasound (RP-EBUS), however, enables far less risky lesion diagnosis. Based on recent research, an image-guided bronchoscopy system can be used to navigate the bronchoscope close to the lesion, while RP-EBUS, which provides real-time extraluminal information on local tissue and lesions, can then be used for lesion localization and biopsy site selection. Unfortunately, physician skill in using RP-EBUS varies greatly, especially for physicians not at expert centers. This results in poor biopsy yields. Also, current state-of-the-art image-guided bronchoscopy systems provide no means for guiding the use of the RP-EBUS. We describe progress toward devising a methodology that facilitates synchronization of the known chest CT-based guidance information to possible locations for invoking RP-EBUS. In particular, we describe a top-level CT-based mechanism that mimics the possible positions of the RP-EBUS probe, supplemented with an approach that simulates possible RP-EBUS views. Results with human patient data demonstrate the potential of the methodology.
AB - For peripheral pulmonary lesion diagnosis, surgical thoracoscopy and percutaneous needle biopsy are common invasive options, but entail significant risks; e.g., percutaneous biopsy carries a 15% pneumothorax rate and risk of other complications. The development of new bronchoscopic devices, such as radial-probe endobronchial ultrasound (RP-EBUS), however, enables far less risky lesion diagnosis. Based on recent research, an image-guided bronchoscopy system can be used to navigate the bronchoscope close to the lesion, while RP-EBUS, which provides real-time extraluminal information on local tissue and lesions, can then be used for lesion localization and biopsy site selection. Unfortunately, physician skill in using RP-EBUS varies greatly, especially for physicians not at expert centers. This results in poor biopsy yields. Also, current state-of-the-art image-guided bronchoscopy systems provide no means for guiding the use of the RP-EBUS. We describe progress toward devising a methodology that facilitates synchronization of the known chest CT-based guidance information to possible locations for invoking RP-EBUS. In particular, we describe a top-level CT-based mechanism that mimics the possible positions of the RP-EBUS probe, supplemented with an approach that simulates possible RP-EBUS views. Results with human patient data demonstrate the potential of the methodology.
UR - https://www.scopus.com/pages/publications/85068888756
UR - https://www.scopus.com/pages/publications/85068888756#tab=citedBy
U2 - 10.1117/12.2505827
DO - 10.1117/12.2505827
M3 - Conference contribution
AN - SCOPUS:85068888756
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2019
A2 - Fei, Baowei
A2 - Linte, Cristian A.
PB - SPIE
T2 - Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling
Y2 - 17 February 2019 through 19 February 2019
ER -