TY - JOUR
T1 - Gut microbiome as a novel cardiovascular therapeutic target
AU - Singh, Vishal
AU - Yeoh, Beng San
AU - Vijay-Kumar, Matam
N1 - Funding Information:
M.V-K. is supported by NIH grant R01 ( DK097865-01A1 ) and American Association of Immunologist Careers in Immunology Fellowship. B.S.Y. is supported by NIH grant T32AI07445 .
Funding Information:
M.V-K. is supported by NIH grant R01 (DK097865-01A1) and American Association of Immunologist Careers in Immunology Fellowship. B.S.Y. is supported by NIH grant T32AI07445.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Over the last two decades, our understanding of gut microbiotal composition and its association with intra-intestinal and extra-intestinal diseases including risk factors of cardiovascular disease (CVD) namely metabolic syndrome and atherosclerosis, have been increased exponentially. A pertinent question which often arises in researchers' community is on how to manipulate the gut microbial ecology to 'cure' the cardiovascular risk factors. Accordingly, in this review we summarized the potential strategies, based on our current knowledge on gut microbiota in modulating CVD, how gut microbiota can be therapeutically exploited by targeting their metabolic activity to alleviate the risk factors of CVD.
AB - Over the last two decades, our understanding of gut microbiotal composition and its association with intra-intestinal and extra-intestinal diseases including risk factors of cardiovascular disease (CVD) namely metabolic syndrome and atherosclerosis, have been increased exponentially. A pertinent question which often arises in researchers' community is on how to manipulate the gut microbial ecology to 'cure' the cardiovascular risk factors. Accordingly, in this review we summarized the potential strategies, based on our current knowledge on gut microbiota in modulating CVD, how gut microbiota can be therapeutically exploited by targeting their metabolic activity to alleviate the risk factors of CVD.
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U2 - 10.1016/j.coph.2016.01.002
DO - 10.1016/j.coph.2016.01.002
M3 - Review article
C2 - 26828626
AN - SCOPUS:84961343396
SN - 1471-4892
VL - 27
SP - 8
EP - 12
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
ER -