TY - JOUR
T1 - Hair color, family history of melanoma, and the risk of Parkinson's disease
T2 - An analysis update
AU - Flores-Torres, Mario H.
AU - Bjornevik, Kjetil
AU - Zhang, Xinyuan
AU - Gao, Xiang
AU - Hung, Albert Y.
AU - Schwarzschild, Michael A.
AU - Chen, Xiqun
AU - Ascherio, Alberto
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2024/2
Y1 - 2024/2
N2 - Background: A shared biological component between melanoma and Parkinson's disease (PD) has been suggested. Yet, epidemiological evidence is scarce. Objective: To examine the association of hair color and family history of melanoma, two strong predictors of melanoma risk, with the occurrence of PD. Methods: We followed 131,342 women and men for ∼30 years for the development of PD. We calculated the cumulative incidence of PD from ages 40 to 90 according to hair color, and estimated the hazard ratio of PD according to hair color and family history of melanoma. Results: Hair color was not strongly associated with the risk of PD, especially at advanced ages. In contrast, individuals with a family history of melanoma had a 1.4-fold higher risk of PD compared to those without a history. Conclusions: Our results support the hypothesis of a shared biological component between PD and melanoma. Both pigmentary and non-pigmentary pathways may play a role.
AB - Background: A shared biological component between melanoma and Parkinson's disease (PD) has been suggested. Yet, epidemiological evidence is scarce. Objective: To examine the association of hair color and family history of melanoma, two strong predictors of melanoma risk, with the occurrence of PD. Methods: We followed 131,342 women and men for ∼30 years for the development of PD. We calculated the cumulative incidence of PD from ages 40 to 90 according to hair color, and estimated the hazard ratio of PD according to hair color and family history of melanoma. Results: Hair color was not strongly associated with the risk of PD, especially at advanced ages. In contrast, individuals with a family history of melanoma had a 1.4-fold higher risk of PD compared to those without a history. Conclusions: Our results support the hypothesis of a shared biological component between PD and melanoma. Both pigmentary and non-pigmentary pathways may play a role.
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U2 - 10.1016/j.parkreldis.2023.105965
DO - 10.1016/j.parkreldis.2023.105965
M3 - Article
C2 - 38142631
AN - SCOPUS:85180586401
SN - 1353-8020
VL - 119
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
M1 - 105965
ER -