Hairy-Cell Leukemia

William Lipera; Lawrence D. Piro; William E. Miller; Carlos J. Carrera; Dennis A. Carson; Ernest Beutler; Robert Silber; W. Christopher Ehmann; William J. Donnelly; Mark J. Ratain; Harvey M. Golomb

doi:10.1056/NEJM198710013171414

Hairy-Cell Leukemia

William Lipera, Lawrence D. Piro, William E. Miller, Carlos J. Carrera, Dennis A. Carson, Ernest Beutler, Robert Silber, W. Christopher Ehmann, William J. Donnelly, Mark J. Ratain, Harvey M. Golomb

Research output: Contribution to journal › Letter › peer-review

30 Scopus citations

Abstract

To the Editor: Spiers et al. (April 2 issue)¹ reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…

Original language	English (US)
Pages (from-to)	901-902
Number of pages	2
Journal	New England Journal of Medicine
Volume	317
Issue number	14
DOIs	https://doi.org/10.1056/NEJM198710013171414
State	Published - Oct 1 1987

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1056/NEJM198710013171414

Cite this

@article{c51b46ac708f4757934ad6d6e5da880b,

title = "Hairy-Cell Leukemia",

abstract = "To the Editor: Spiers et al. (April 2 issue)1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…",

author = "William Lipera and Piro, {Lawrence D.} and Miller, {William E.} and Carrera, {Carlos J.} and Carson, {Dennis A.} and Ernest Beutler and Robert Silber and Ehmann, {W. Christopher} and Donnelly, {William J.} and Ratain, {Mark J.} and Golomb, {Harvey M.}",

year = "1987",

month = oct,

day = "1",

doi = "10.1056/NEJM198710013171414",

language = "English (US)",

volume = "317",

pages = "901--902",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "14",

}

TY - JOUR

T1 - Hairy-Cell Leukemia

AU - Lipera, William

AU - Piro, Lawrence D.

AU - Miller, William E.

AU - Carrera, Carlos J.

AU - Carson, Dennis A.

AU - Beutler, Ernest

AU - Silber, Robert

AU - Ehmann, W. Christopher

AU - Donnelly, William J.

AU - Ratain, Mark J.

AU - Golomb, Harvey M.

PY - 1987/10/1

Y1 - 1987/10/1

N2 - To the Editor: Spiers et al. (April 2 issue)1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…

AB - To the Editor: Spiers et al. (April 2 issue)1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…

UR - http://www.scopus.com/inward/record.url?scp=0023639754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023639754&partnerID=8YFLogxK

U2 - 10.1056/NEJM198710013171414

DO - 10.1056/NEJM198710013171414

M3 - Letter

C2 - 3498119

AN - SCOPUS:0023639754

SN - 0028-4793

VL - 317

SP - 901

EP - 902

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 14

ER -

Hairy-Cell Leukemia

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this