Hairy-Cell Leukemia

William Lipera, Lawrence D. Piro, William E. Miller, Carlos J. Carrera, Dennis A. Carson, Ernest Beutler, Robert Silber, W. Christopher Ehmann, William J. Donnelly, Mark J. Ratain, Harvey M. Golomb

Research output: Contribution to journalLetterpeer-review

30 Scopus citations


To the Editor: Spiers et al. (April 2 issue)1 reported impressive response rates in hairy-cell leukemia treated with pentostatin (2′-deoxycoformycin). Pentostatin is an inhibitor of adenosine deaminase in the pathway of purine metabolism. The authors point out that inhibition of adenosine deaminase leads to accumulation of deoxyadenosine and deoxy-ATP, both of which interfere with DNA synthesis. The malignant cell in hairy-cell leukemia contains low levels of adenosine deaminase and is sensitive to pentostatin. All the patients in this study also received allopurinol to prevent excessive uric acid formation. The authors did not, however, discuss the possible role of allopurinol in…

Original languageEnglish (US)
Pages (from-to)901-902
Number of pages2
JournalNew England Journal of Medicine
Issue number14
StatePublished - Oct 1 1987

All Science Journal Classification (ASJC) codes

  • General Medicine


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