TY - JOUR
T1 - Heat Shock Protein Reports on Proteome Stress
AU - Liu, Yu
AU - Zhang, Xin
N1 - Funding Information:
This work is supported by the Burroughs Wellcome Fund Career Award at the Scientific Interface, Paul Berg Early Career Professorship, and Lloyd and Dottie Huck Early Career Award.
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/4
Y1 - 2018/4
N2 - Proper regulation of protein homeostasis (proteostasis) is essential to maintain cellular fitness. Proteome stress causes imbalance of the proteostasis, leading to various diseases represented by neurodegenerative diseases, cancers, and metabolic disorders. The biosensor community recently embarked on the development of proteome stress sensors to report on the integrity of proteostasis in live cells. While most of these sensors are based on metastable mutants of specific client proteins, a recent sensor takes advantage of the specific association of heat shock protein 27 with protein aggregates and exhibits a diffusive to punctate fluorescent change in cells that are subjected to stress conditions. Thus, heat shock proteins can be also used as a family of sensors to monitor proteome stress.
AB - Proper regulation of protein homeostasis (proteostasis) is essential to maintain cellular fitness. Proteome stress causes imbalance of the proteostasis, leading to various diseases represented by neurodegenerative diseases, cancers, and metabolic disorders. The biosensor community recently embarked on the development of proteome stress sensors to report on the integrity of proteostasis in live cells. While most of these sensors are based on metastable mutants of specific client proteins, a recent sensor takes advantage of the specific association of heat shock protein 27 with protein aggregates and exhibits a diffusive to punctate fluorescent change in cells that are subjected to stress conditions. Thus, heat shock proteins can be also used as a family of sensors to monitor proteome stress.
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U2 - 10.1002/biot.201800039
DO - 10.1002/biot.201800039
M3 - Comment/debate
C2 - 29461669
AN - SCOPUS:85043277598
SN - 1860-6768
VL - 13
JO - Biotechnology Journal
JF - Biotechnology Journal
IS - 4
ER -