Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

Abilasha Rao-Bhatia; Min Zhu; Wen Chi Yin; Sabrina Coquenlorge; Xiaoyun Zhang; Janghee Woo; Yu Sun; Charlotte H. Dean; Aimin Liu; Chi chung Hui; Ramesh A. Shivdasani; Helen McNeill; Sevan Hopyan; Tae Hee Kim

doi:10.1016/j.devcel.2020.02.003

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

Abilasha Rao-Bhatia, Min Zhu, Wen Chi Yin, Sabrina Coquenlorge, Xiaoyun Zhang, Janghee Woo, Yu Sun, Charlotte H. Dean, Aimin Liu, Chi chung Hui, Ramesh A. Shivdasani, Helen McNeill, Sevan Hopyan, Tae Hee Kim

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Rao-Bhatia et al. investigate the signaling mechanisms of cell behavior during mammalian villus morphogenesis. They demonstrate that Hh signaling in the intestinal mesenchyme directly activates planar cell polarity genes, thereby regulating the stromal cell clustering behavior required for epithelial remodeling in villus formation.

Original language	English (US)
Pages (from-to)	647-658.e6
Journal	Developmental Cell
Volume	52
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2020.02.003
State	Published - Mar 9 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2020.02.003

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Rao-Bhatia, A., Zhu, M., Yin, W. C., Coquenlorge, S., Zhang, X., Woo, J., Sun, Y., Dean, C. H., Liu, A., Hui, C. C., Shivdasani, R. A., McNeill, H., Hopyan, S., & Kim, T. H. (2020). Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Developmental Cell, 52(5), 647-658.e6. https://doi.org/10.1016/j.devcel.2020.02.003

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title = "Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development",

abstract = "Rao-Bhatia et al. investigate the signaling mechanisms of cell behavior during mammalian villus morphogenesis. They demonstrate that Hh signaling in the intestinal mesenchyme directly activates planar cell polarity genes, thereby regulating the stromal cell clustering behavior required for epithelial remodeling in villus formation.",

author = "Abilasha Rao-Bhatia and Min Zhu and Yin, {Wen Chi} and Sabrina Coquenlorge and Xiaoyun Zhang and Janghee Woo and Yu Sun and Dean, {Charlotte H.} and Aimin Liu and Hui, {Chi chung} and Shivdasani, {Ramesh A.} and Helen McNeill and Sevan Hopyan and Kim, {Tae Hee}",

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year = "2020",

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doi = "10.1016/j.devcel.2020.02.003",

language = "English (US)",

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Rao-Bhatia, A, Zhu, M, Yin, WC, Coquenlorge, S, Zhang, X, Woo, J, Sun, Y, Dean, CH, Liu, A, Hui, CC, Shivdasani, RA, McNeill, H, Hopyan, S & Kim, TH 2020, 'Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development', Developmental Cell, vol. 52, no. 5, pp. 647-658.e6. https://doi.org/10.1016/j.devcel.2020.02.003

TY - JOUR

T1 - Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

AU - Rao-Bhatia, Abilasha

AU - Zhu, Min

AU - Yin, Wen Chi

AU - Coquenlorge, Sabrina

AU - Zhang, Xiaoyun

AU - Woo, Janghee

AU - Sun, Yu

AU - Dean, Charlotte H.

AU - Liu, Aimin

AU - Hui, Chi chung

AU - Shivdasani, Ramesh A.

AU - McNeill, Helen

AU - Hopyan, Sevan

AU - Kim, Tae Hee

PY - 2020/3/9

Y1 - 2020/3/9

N2 - Rao-Bhatia et al. investigate the signaling mechanisms of cell behavior during mammalian villus morphogenesis. They demonstrate that Hh signaling in the intestinal mesenchyme directly activates planar cell polarity genes, thereby regulating the stromal cell clustering behavior required for epithelial remodeling in villus formation.

AB - Rao-Bhatia et al. investigate the signaling mechanisms of cell behavior during mammalian villus morphogenesis. They demonstrate that Hh signaling in the intestinal mesenchyme directly activates planar cell polarity genes, thereby regulating the stromal cell clustering behavior required for epithelial remodeling in villus formation.

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DO - 10.1016/j.devcel.2020.02.003

M3 - Article

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AN - SCOPUS:85080958194

SN - 1534-5807

VL - 52

SP - 647-658.e6

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

Abstract

All Science Journal Classification (ASJC) codes

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