TY - JOUR
T1 - Hemimegalencephalic appearance of normal hemisphere in unilateral heterotopia and absent corpus callosum
AU - Raghavendra, S.
AU - Thamburaj, Krishnamoorthy
AU - Ashalatha, R.
AU - Nayak, S. Dinesh
AU - Radhakrishnan, K.
PY - 2006/9
Y1 - 2006/9
N2 - We report two patients with medically refractory epilepsy who had MRI evidence of unilateral subcortical nodular heterotopia and agenesis of corpus callosum. The abnormal hemisphere was small, whereas the contralateral normal hemisphere appeared large and crossed the midline. Although the normal hemisphere was initially mistaken for hemimegalencephaly, there were no typical radiological features. Moreover, the electroencephalographic abnormalities lateralized to the hemisphere showing heterotopia. Because contralateral hemispheric abnormalities like heterotopia, hemimicrencephaly, and hemimegalencephaly can occur in patients with hemispheric heterotopias, we emphasize the importance of careful scrutiny of the contralateral hemisphere in patients with unilateral heterotopia. Absence of typical radiological features and appropriately lateralized electroencephalographic abnormalities will help differentiate the two. This is crucial when planning epilepsy surgery.
AB - We report two patients with medically refractory epilepsy who had MRI evidence of unilateral subcortical nodular heterotopia and agenesis of corpus callosum. The abnormal hemisphere was small, whereas the contralateral normal hemisphere appeared large and crossed the midline. Although the normal hemisphere was initially mistaken for hemimegalencephaly, there were no typical radiological features. Moreover, the electroencephalographic abnormalities lateralized to the hemisphere showing heterotopia. Because contralateral hemispheric abnormalities like heterotopia, hemimicrencephaly, and hemimegalencephaly can occur in patients with hemispheric heterotopias, we emphasize the importance of careful scrutiny of the contralateral hemisphere in patients with unilateral heterotopia. Absence of typical radiological features and appropriately lateralized electroencephalographic abnormalities will help differentiate the two. This is crucial when planning epilepsy surgery.
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U2 - 10.1016/j.yebeh.2006.06.006
DO - 10.1016/j.yebeh.2006.06.006
M3 - Article
C2 - 16899411
AN - SCOPUS:33747834315
SN - 1525-5050
VL - 9
SP - 363
EP - 366
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 2
ER -