TY - JOUR
T1 - Hemophagocytic Lymphohistiocytosis induced by human granulocytic anaplasmosis
T2 - A case report and literature review into the immunopathogenesis
AU - Zhang, Yong
AU - Chen, Tiane
AU - Polimera, Hyma
AU - Evans, Matthew
AU - Bayerl, Michael G.
AU - George, Melissa R.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/3
Y1 - 2022/3
N2 - Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous collection of immunological disorders characterized by severely disrupted immune homeostasis and dysregulated macrophage overactivation resulting in hyperinflammation, hypercytokinemia, histiocytic phagocytosis in hematolymphoid systems, and life-threatening organ damage. Human granulocytic anaplasmosis (HGA) is caused by Anaplasma phagocytophilum (Ap), one of the most common tick-borne diseases in North America and worldwide. The pathophysiology by which anaplasmosis triggers the development of human HLH remains unclear. Herein, we report a case of severe Anaplasma infection in Central Pennsylvania presenting with classical clinical features and laboratory findings of acquired, secondary HLH. From basic science to clinicopathological studies, we review and summarize the literature emphasizing the unique immunopathogenesis that informs diagnosis and management of Anaplasma-induced HLH.
AB - Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous collection of immunological disorders characterized by severely disrupted immune homeostasis and dysregulated macrophage overactivation resulting in hyperinflammation, hypercytokinemia, histiocytic phagocytosis in hematolymphoid systems, and life-threatening organ damage. Human granulocytic anaplasmosis (HGA) is caused by Anaplasma phagocytophilum (Ap), one of the most common tick-borne diseases in North America and worldwide. The pathophysiology by which anaplasmosis triggers the development of human HLH remains unclear. Herein, we report a case of severe Anaplasma infection in Central Pennsylvania presenting with classical clinical features and laboratory findings of acquired, secondary HLH. From basic science to clinicopathological studies, we review and summarize the literature emphasizing the unique immunopathogenesis that informs diagnosis and management of Anaplasma-induced HLH.
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U2 - 10.1016/j.hpr.2022.300598
DO - 10.1016/j.hpr.2022.300598
M3 - Article
AN - SCOPUS:85124486852
SN - 2772-736X
VL - 27
JO - Human Pathology Reports
JF - Human Pathology Reports
M1 - 300598
ER -
