Hemophilia morbidity, cognitive functioning, and academic achievement

D. W. Usner, S. M. Donfield, P. A. Sirois, E. D. Gomperts, Jr Bale, W. G. Mitchell, W. Y. Wong, F. Kaufman, M. Nelson, S. Pearson, M. Hilgartner, S. Cunningham-Rundles, I. Goldberg, W. K. Hoots, K. Loveland, M. Cantini, A. Willoughby, S. McKinlay, M. A. Maeder, S. DonfieldJr Contant C., C. T. Kisker, J. Stehbens, S. O'Conner, J. McKillip, P. Sirois, C. Sexauer, H. Huszti, F. Kipliner, S. Hawk, S. Arkin, A. Forster, S. Swindells, S. Richard, J. Mangoes, A. Scott, R. Davis, J. Lusher, I. Warrier, K. Baird-Cox, M. E. Eyster, D. Ungar, S. Neagley, A. Shapiro, J. Morris, G. Davignon, P. Mollen, B. Wicklund, A. Mehrhof

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Data from the Hemophilia Growth and Development Study (HGDS) were used to evaluate the association between hemophilia morbidity, measured by abnormalities in coordination and gait (CG), and intellectual ability and academic achievement. The CG abnormalities observed in the HGDS participants (n = 333) were primarily due to hemophilia-related morbidity. Although HGDS participants performed within the average range for age on measures of intellectual ability, there were meaningful differences between CG outcomes at baseline and throughout the 4 years of study. Participants without CG abnormalities consistently achieved higher scores than those with CG abnormalities on Reading, Spelling, and Arithmetic subtests of the Wide Range Achievement Test-Revised. Our findings suggest that lowered achievement is related to the functional severity of hemophilia.

Original languageEnglish (US)
Pages (from-to)782-787
Number of pages6
JournalJournal of Pediatrics
Issue number6
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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