TY - JOUR
T1 - Hemostatic abnormalities associated with prolonged ventricular assist pumping
T2 - Analysis of 24 patients
AU - Al-Mondhiry, Hamid
AU - Pierce, William S.
AU - Richenbacher, Wayne
AU - Bull, Anthony
N1 - Funding Information:
From the Division of Hematology, Department of Medicine and the Division of Cardiovascular Surgery, Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. This study was supported in part by Research Grant 5 ROl l-IL13426 from the U.S. Public Health Service, Bethesda, Maryland, The McKean County Cardiac Committee, Bradford, Pennsylvania, The Whitaker Foundation, wisburg, Pennsylvania, The H. G. Barsumian, M.D. Trust Fund, Lancaster, Pennsytvania,a nd a gift from Professor and Mrs. Robert E. GalbraithS, tate College. Pennsylvania. Manuscript received Dctober 11, 1983; revised manuscript received December 29, 1983, accepted January 3, 1984.
PY - 1984/5/1
Y1 - 1984/5/1
N2 - Bleeding remains a serious problem in patients with ventricular assist pumping (VAP). Clinical and hemostatic laboratory data in 24 patients who could not be separated from cardiopulmonary bypass (CPB) at the conclusion of open heart surgery and who underwent VAP for 54 to 610 hours were analyzed. The most important variable that correlated with the occurrence of severe bleeding was the duration of CPB: 5.2 ± 1.6 hours in 13 patients with excessive bleeding, vs 3.6 ± 1.1 hours in 11 patients with "acceptable" levels of bleeding (p < 0.01). Moderate thrombocytopenia occurred in all patients but did not appear to be a major contributing factor to excessive bleeding. Disseminated intravascular coagulation (DIG) occurred in 12 patients, 4 of whom were in cardiogenic shock. DiC also correlated with time on CPB: 5.2 ± 1.7 hours for patients with DIC, vs 3.7 ± 1.1 hours for patients without DIC (p < 0.01). No correlation was noted between the duration of VAP and the occurrence of DIC or bleeding.
AB - Bleeding remains a serious problem in patients with ventricular assist pumping (VAP). Clinical and hemostatic laboratory data in 24 patients who could not be separated from cardiopulmonary bypass (CPB) at the conclusion of open heart surgery and who underwent VAP for 54 to 610 hours were analyzed. The most important variable that correlated with the occurrence of severe bleeding was the duration of CPB: 5.2 ± 1.6 hours in 13 patients with excessive bleeding, vs 3.6 ± 1.1 hours in 11 patients with "acceptable" levels of bleeding (p < 0.01). Moderate thrombocytopenia occurred in all patients but did not appear to be a major contributing factor to excessive bleeding. Disseminated intravascular coagulation (DIG) occurred in 12 patients, 4 of whom were in cardiogenic shock. DiC also correlated with time on CPB: 5.2 ± 1.7 hours for patients with DIC, vs 3.7 ± 1.1 hours for patients without DIC (p < 0.01). No correlation was noted between the duration of VAP and the occurrence of DIC or bleeding.
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U2 - 10.1016/0002-9149(84)90091-2
DO - 10.1016/0002-9149(84)90091-2
M3 - Article
C2 - 6711436
AN - SCOPUS:0021220845
SN - 0002-9149
VL - 53
SP - 1344
EP - 1348
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 9
ER -