Hepatitis C virus infection: detection and treatment.

Matthew L. Rubinstein, Mary E. Miele

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Hepatitis C virus (HCV) is a blood-borne virus that infects the liver. HCV affects millions of Americans, and poses a serious public health threat with sequelae such as cirrhosis, hepatocellular carcinoma, and liver failure. This paper reviews means of transmission, characteristics of the various risk groups, and clinical presentations of both the acute and chronic stages of HCV infection. Diagnostic methods, including screening and confirmatory tests, along with relevant clinical and physiologic findings are also described. Additionally, treatment strategies, in particular combination therapy with interferon alpha-2b and ribavirin, are discussed. Contraindications, side effects, and monitoring of this therapeutic modality are considered. Finally, prospective treatments are presented.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalClinical laboratory science : journal of the American Society for Medical Technology
Issue number4
StatePublished - Sep 1 2003

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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