@article{c98d9fc0b46d4c66924364631e280be2,
title = "Hepatitis C virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs",
abstract = "Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) coinfection is common in hemophiliacs and injection drug users. To assess the interaction between HCV load and HIV-1 disease progression, we examined 207 HIV-1/HCV-coinfected patients. Patients were followed prospectively for ∼7 years, and annual measurements of CD4+ cell counts and HCV and HIV-1 loads were obtained. Survival analysis was used to define the independent effects of HCV load on HIV-1 progression. After controlling for CD4+ cell count and HIV-1 RNA level, every 10-fold increase in baseline HCV RNA was associated with a relative risk (RR) for clinical progression to acquired immunodeficiency syndrome (AIDS) of 1.66 (95% confidence interval [CI], 1.10-2.51; P = .016) and an RR for AIDS-related mortality of 1.54 (95% CI, 1.03-2.30; P = .036). These findings emphasize the need for further research regarding the use of HIV-1- and HCV-specific therapy in coinfected individuals.",
author = "{Hemophilia Growth and Development Study} and Daar, {Eric S.} and Henry Lynn and Sharyne Donfield and Edward Gomperts and O{\textquoteright}brien, {Stephen J.} and Hilgartner, {Margaret W.} and Hoots, {W. Keith} and David Chernoff and Steven Arkin and Wong, {W. Y.} and Winkler, {Cheryl A.} and E. Gomperts and Wong, {W. Y.} and F. Kaufman and M. Nelson and S. Pearson and M. Hilgartner and S. Cunningham-Rundles and I. Goldberg and Hoots, {W. K.} and K. Loveland and M. Cantini and A. Willoughby and S. McKinlay and S. Donfield and C. Contant and Kisker, {C. T.} and J. Stehbens and S. O{\textquoteright}conner and J. McKillip and P. Sirois and C. Sexauer and H. Huszti and F. Kiplinger and S. Hawk and S. Arkin and A. Forster and S. Swindells and S. Richard and J. Mangos and A. Scott and R. Davis and J. Lusher and I. Warrier and K. Baird-Cox and Eyster, {M. E.} and D. Ungar and S. Neagley and A. Shapiro and J. Morris",
note = "Funding Information: Financial support: National Center for Research Resources of the National Institutes of Health (grant MO1-RR06020 to New York Hospital– Cornell Medical Center Clinical Research Center), Mount Sinai General Clinical Research Center (MO1-RR00071), University of Iowa Clinical Research Center (MO1-RR00059), and University of Texas Health Science Center (MO1-RR02558). The Hemophilia Growth and Development Study is supported by the Bureau of Maternal and Child Health and Resources Development (MCJ-060570), the National Institute of Child Health and Human Development (NO1-HD-4-3200), the Centers for Disease Control and Prevention, the National Cancer Institute (NO1-CO-56000), and the National Institute of Mental Health. E.S.D. is supported in part by the Women{\textquoteright}s Guild, Cedars-Sinai Medical Center.",
year = "2001",
month = feb,
day = "15",
doi = "10.1086/318539",
language = "English (US)",
volume = "183",
pages = "589--595",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}