TY - JOUR
T1 - Hepatotoxicity of antibiotics. A review and update for the clinician.
AU - Stine, Jonathan G.
AU - Lewis, James H.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Collectively, the various classes of antibiotics are a leading cause of drug-induced liver injury (DILI). However, acute antibiotic-associated DILI can be difficult to diagnose, as the course of therapy is usually brief, and other confounding factors are often present. In addition to the broad clinicopathologic spectrum of hepatotoxicity associated with the antimicrobials, the underlying infectious disease being treated may itself be associated with hepatic dysfunction and jaundice. This review provides summarized information on several classes of antimicrobial agents, highlighting new agents causing DILI and updating information on older agents.
AB - Collectively, the various classes of antibiotics are a leading cause of drug-induced liver injury (DILI). However, acute antibiotic-associated DILI can be difficult to diagnose, as the course of therapy is usually brief, and other confounding factors are often present. In addition to the broad clinicopathologic spectrum of hepatotoxicity associated with the antimicrobials, the underlying infectious disease being treated may itself be associated with hepatic dysfunction and jaundice. This review provides summarized information on several classes of antimicrobial agents, highlighting new agents causing DILI and updating information on older agents.
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U2 - 10.1016/j.cld.2013.07.008
DO - 10.1016/j.cld.2013.07.008
M3 - Review article
C2 - 24099021
AN - SCOPUS:84884974812
SN - 1089-3261
VL - 17
SP - 609
EP - 642
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
IS - 4
ER -