Hereditary angioedema in children and adolescents

Eli Mansour, Camila L. Veronez, Timothy Craig, Anete Sevciovic Grumach

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting subcutaneous and mucus membranes with variable onset and severity. More than 50% of patients may become symptomatic before 10 years of age. Family history can help with the diagnosis; however, approximately 25% of the cases are de novo mutations. Biochemical diagnosis should be delayed until after 1 year of age. Children were often excluded from advances in therapy for hereditary angioedema since most of the new medicines were tested in adults and thus excluded by the Food and Drug Administration (FDA) and other agencies for approval to be used in children. Treatment of attacks is available for the pediatric patient; however, barriers still exist for the use of long-term prophylaxis in young children.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalAllergologia et Immunopathologia
Volume50
Issue numberSpecialIssue1
DOIs
StatePublished - 2022

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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