TY - JOUR
T1 - Heroin-induced suppression of saccharin intake in water-deprived and water-replete rats
AU - Grigson, Patricia S.
AU - Twining, Robert C.
AU - Carelli, Regina M.
N1 - Funding Information:
This research was supported by the U.S. Public Health Service Grants DA 09815 and DC 02016 to P.S.G., and DA 10006 to R.M.C. The authors would like to thank the National Institute on Drug Abuse for generously providing the heroin, and Stephanie Ijames and Allison Crumling for technical assistance.
PY - 2000/7
Y1 - 2000/7
N2 - Rats suppress intake of a saccharin conditioned stimulus (CS) when paired with an aversive unconditioned stimulus such as lithium chloride. This phenomenon is referred to as a conditioned taste aversion (CTA). Rats also suppress intake of a saccharin CS when paired with a rewarding sucrose solution and when paired with a drug of abuse. Although the suppressive effects of drugs of abuse have long been interpreted as CTAs, evidence suggests that rats may suppress intake of the saccharin CS following taste-drug pairings because they are anticipating the rewarding rather than the aversive properties of the drug. Oddly, however, while all other drugs of abuse tested suppress intake of a gustatory CS, the highly reinforcing drug, heroin, is reportedly ineffective. The present study reexamined this issue in both water-deprived and water-replete rats using procedures that sustain both morphine- and cocaine-induced suppression of CS intake. The results showed that heroin greatly reduced CS intake following saccharin-heroin pairings and that this effect was less variable when assessed in water-replete subjects. When taken with other reports, these data suggest that rats suppress intake of a saccharin CS in anticipation of the availability of all drugs of abuse tested. Copyright (C) 2000 Elsevier Science Inc.
AB - Rats suppress intake of a saccharin conditioned stimulus (CS) when paired with an aversive unconditioned stimulus such as lithium chloride. This phenomenon is referred to as a conditioned taste aversion (CTA). Rats also suppress intake of a saccharin CS when paired with a rewarding sucrose solution and when paired with a drug of abuse. Although the suppressive effects of drugs of abuse have long been interpreted as CTAs, evidence suggests that rats may suppress intake of the saccharin CS following taste-drug pairings because they are anticipating the rewarding rather than the aversive properties of the drug. Oddly, however, while all other drugs of abuse tested suppress intake of a gustatory CS, the highly reinforcing drug, heroin, is reportedly ineffective. The present study reexamined this issue in both water-deprived and water-replete rats using procedures that sustain both morphine- and cocaine-induced suppression of CS intake. The results showed that heroin greatly reduced CS intake following saccharin-heroin pairings and that this effect was less variable when assessed in water-replete subjects. When taken with other reports, these data suggest that rats suppress intake of a saccharin CS in anticipation of the availability of all drugs of abuse tested. Copyright (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S0091-3057(00)00253-7
DO - 10.1016/S0091-3057(00)00253-7
M3 - Article
C2 - 10899377
AN - SCOPUS:0033921875
SN - 0091-3057
VL - 66
SP - 603
EP - 608
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 3
ER -