TY - JOUR
T1 - Heterogeneity of GABAA-receptors
T2 - cell-specific expression, pharmacology, and regulation
AU - Mohler, H.
AU - Knoflach, F.
AU - Paysan, J.
AU - Motejlek, K.
AU - Benke, D.
AU - Luscher, Bernhard
AU - Fritschy, J. M.
PY - 1995/5/1
Y1 - 1995/5/1
N2 - Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinatorial assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.
AB - Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinatorial assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.
UR - http://www.scopus.com/inward/record.url?scp=0028978201&partnerID=8YFLogxK
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U2 - 10.1007/BF01694546
DO - 10.1007/BF01694546
M3 - Article
C2 - 7643969
AN - SCOPUS:0028978201
SN - 0364-3190
VL - 20
SP - 631
EP - 636
JO - Neurochemical Research
JF - Neurochemical Research
IS - 5
ER -