Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation

H. Mohler; F. Knoflach; J. Paysan; K. Motejlek; D. Benke; Bernhard Luscher; J. M. Fritschy

doi:10.1007/BF01694546

Heterogeneity of GABA_A-receptors: cell-specific expression, pharmacology, and regulation

H. Mohler, F. Knoflach, J. Paysan, K. Motejlek, D. Benke, Bernhard Luscher, J. M. Fritschy

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABA_A-receptor function. A multitude of different GABA_A-receptors exist in the brain due to the combinatorial assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABA_A-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

Original language	English (US)
Pages (from-to)	631-636
Number of pages	6
Journal	Neurochemical Research
Volume	20
Issue number	5
DOIs	https://doi.org/10.1007/BF01694546
State	Published - May 1 1995

All Science Journal Classification (ASJC) codes

Biochemistry
Cellular and Molecular Neuroscience

Access to Document

10.1007/BF01694546

Cite this

@article{edd87c990d90405eb8eb31e5c4dc2e6c,

title = "Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation",

abstract = "Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinatorial assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.",

author = "H. Mohler and F. Knoflach and J. Paysan and K. Motejlek and D. Benke and Bernhard Luscher and Fritschy, {J. M.}",

year = "1995",

month = may,

day = "1",

doi = "10.1007/BF01694546",

language = "English (US)",

volume = "20",

pages = "631--636",

journal = "Neurochemical Research",

issn = "0364-3190",

publisher = "Springer New York",

number = "5",

}

TY - JOUR

T1 - Heterogeneity of GABAA-receptors

T2 - cell-specific expression, pharmacology, and regulation

AU - Mohler, H.

AU - Knoflach, F.

AU - Paysan, J.

AU - Motejlek, K.

AU - Benke, D.

AU - Luscher, Bernhard

AU - Fritschy, J. M.

PY - 1995/5/1

Y1 - 1995/5/1

N2 - Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinatorial assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

AB - Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinatorial assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

UR - http://www.scopus.com/inward/record.url?scp=0028978201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028978201&partnerID=8YFLogxK

U2 - 10.1007/BF01694546

DO - 10.1007/BF01694546

M3 - Article

C2 - 7643969

AN - SCOPUS:0028978201

SN - 0364-3190

VL - 20

SP - 631

EP - 636

JO - Neurochemical Research

JF - Neurochemical Research

IS - 5

ER -

Heterogeneity of GABA_A-receptors: cell-specific expression, pharmacology, and regulation

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this